We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance th...

This paper uses the thermodynamic data of aqueous solutions of uncrosslinked poly(N-isopropylacrylamide) (PNIPAM) to study the phase transition of PNIPAM hydrogels. At a low temperature, uncrosslinked PNIPAM can be dissolved in water and form a homogenous liquid solution. When the temperature is increased, the solution separates into two liquid phases with different concentrations of the polyme...

New hydrogels having the tubular structure of a-cyclodextrins (a-CDs) crosslinked by poly(ethylene glycol) (PEG) (MT-PEG hydrogels) were prepared by using a hydrolyzable polyrotaxane. The hydrolyzable polyrotaxane, in which many a-CDs are threaded onto a PEG chain capped by a hydrolyzable ester moiety, was used to form a tubular structure in the hydrogel. After crosslinking with another PEG cha...

By taking advantage of cellulose, graphene oxide (GO), and the process for crosslinking using epichlorohydrin (ECH), we propose a simple and novel method to prepare GO/cellulose hydrogel with good potential to adsorb metal ions. GO nanosheets containing carboxyl and hydroxyl groups were introduced into the surface of the cellulose hydrogel with retention of the gel structure and its nanoporous ...

Bacterial cellulose and gelatin were successfully used to develop a hydrogel composite material. Hydrogel was synthesized by copolymerization between bacterial cellulose and gelatin. Scanning electron microscopy (SEM) images showed that the bacterial cellulose chain was uniform in size and shape. Glutaraldehyde was employed as a crosslinking agent. H-bonds were formed via the reaction between t...

A hydrogel pen consisting of a microscopic pyramid containing an electrolyte offers a localized electroactive area on the nanometer scale via controlled contact of the apex with a working electrode. The hydrogel pen merges the fine control of atomic force microscopy with non-linear diffusion of an ultramicroelectrode, producing a faradaic current that depends on the small electroactive area. Th...

In this study, the synthesis of silk fibroin (SF) hydrogel via chemical cross-linking reactions of SF due to gamma-ray (γ-ray) irradiation was investigated, as were the resultant hydrogel's properties. Two different hydrogels were investigated: physically cross-linked SF hydrogel and chemically cross-linked SF hydrogel irradiated at different doses of γ-rays. The effects of the irradiation dose...

With the rapid progress of tissue engineering and regenerative medicine, the cell-friendly construction of a 3D extracellular matrix in a precisely controlled manner is needed. This biomimicry of the native extracellular matrix replicates major aspects of the native cellular microenvironment. Herein, we design a polyethylene glycol (PEG) based hydrogel combined with caging chemistry, which coul...

The composition of the dressings is based on polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and agar. The electron beam irradiation technique has been used to prepare hydrogel wound dressings. The in vitro biocompatibility of the hydrogel was investigated by check samples (hydrocolloid Comfeel), antibacterial test (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginos...

Cellular communities in living tissues act in concert to establish intricate microenvironments, with complexity difficult to recapitulate in vitro. We report a method for docking numerous cellularized hydrogel shapes (100-1,000 µm in size) into hydrogel templates to construct 3D cellular microenvironments. Each shape can be uniquely designed to contain customizable concentrations of cells and m...