Different formulations of Indapamide 1.5mg sustained release tablets were formulated using wet granulation method using hydrophilic polymer. The tablets were subjected to physicochemical studies, in vitro release studies, kinetic modeling and stability studies to find out the best formulation. The in vitro release studies were conducted for 16 hours using USP 30 apparatus type I (Basket method)...

The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. The matrix swelling behavior was investigated. The dissolution profiles of each...

Hydrophilic interaction chromatography (HILIC) was first introduced by Alpert in 1990 [...]

In recent years, natural fibers reinforced composites have received much attention because of their lightweight, recyclable, nontoxic, low cost and biodegradable properties. However, compatibility between hydrophilic fiber hydrophobic polymer is low. One way to increase the fiber/matrix treat surface, using hydroxyl groups present on upper layer high tenacity viscose. are not always accessible ...

The objective of the present investigation was to study the effect of critical formulation parameters affecting release of isoxsuprine hydrochloride from matrix tablets using combination of polyethylene oxide (PEO) and dicalcium phosphate (DCP). The powder blend consisting of drug and excipients was analyzed for angle of repose, Carr’s index and Hausner’s ratio. The tablets were prepared by dir...

Environmental concerns have led to a rapid growing interest in replacing traditional petroleum-based technology with more green alternatives. Cellulose, one of the main components in plants, is a biodegradable and renewable recourse. The use of cellulose fibers, instead of traditional fibers such as glass and carbon, offers a way to make more environmental friendly biocomposites. By replacing t...

Abstract Herein, we report a dual-modified organic-inorganic separator as an alternative to polyolefin commercial for lithium metal batteries. This composite exhibits high thermal stability properties due the use of engineering plastic matrix poly (arylene ether nitriles) (PEN). The dual hydrophilic modification strategy also allows have ionic conductivity and low interfacial impedance. With th...

aqueous (hydrophilic) and chloroform (lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in egypt, to treat some gastrointestinal tract (git) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. indomethacin-induced ulcer in a rat model was used for this testing. mentha microphylla, brassica oleracea capitata (cabbage...

The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on drug release from valproic acid-sodium valproate matrix tablets prepared with w...