Interactions between nanoparticles and cell membranes may play a crucial role in determining the cytotoxicity of nanoparticles as well as their potential application as drug delivery vehicles or therapeutic agents. It has been shown that such interactions are often determined not by biochemical but by physicochemical factors (e.g., nanoparticle size, hydrophobicity, and surface charge density)....

A gold nanoparticle (AuNP)-capped mesoporous silica nanosphere (MSN)-based intracellular drug delivery system (PR-AuNPs-MSN) for the photoinduced controlled release of an anticancer drug, paclitaxel, inside of human fibroblast and liver cells was synthesized and characterized. We found that the mesopores of MSN could be efficiently capped by the photoresponsive AuNPs without leaking the toxic d...

Silk fibroin (SF) is a protein with bulky hydrophobic domains and can be easily purified as sericin-free silk-based biomaterial. Silk fibroin modified chitosan nanoparticle (SF-CSNP), a biocompatible material, has been widely used as a potential drug delivery system. Our current investigation studied the bio-effects of the SF-CSNP uptake by liver cells. In this experiment, the characterizations...

Understanding the phenomenon of droplet coalescence in nanoparticle suspensions is extremely important for the preparation of Pickering emulsions. A microfluidic platform, which can provide compulsive droplet collisions, was developed to imitate the droplet coalescence process in the early stages of emulsification. Microscope videos showed the variations in the droplet coalescence percentage, d...

We designed a biodegradable nanocarrier of layered double hydroxide (LDH) for photodynamic therapy (PDT) based on the intercalation of a palladium porphyrin photosensitizer (PdTCPP) in the gallery of LDH for melanoma theragnosis. Physical and chemical characterizations have demonstrated the photosensitizer was stable in the layered structures. In addition, the synthesized nanocomposites rendere...

Diamondoids are promising materials for applications in catalysis and nanotechnology. Since many of their aqueous environments, to understand function it is essential know the structure dynamics water molecules first hydration shells. In this study, we adapt a reactive force field (ReaxFF) atomistically resolved molecular simulations hydrated diamondoids characterize interfacial structure. We p...

Cellular senescence is the results of aging and age-related diseases, development anti-aging methods may improve health extend longevity. The natural flavonol fisetin has been shown to antagonize in vitro increases longevity vivo, but poor water solubility limited bioavailability. In this study, a food-grade senescent cell-targeted delivery system for was developed based on whey prot...

The elastic modulus of polymeric membranes based on PVOH + H3PO2 TiO2 was studied as a function relative humidity (%RH) and the volumetric fraction water. Tensile stress-strain tests (nominal stress) were performed to determine Young's modulus, yield strength, break stress, strain stress at constant speed 10 mm/min. membrane’s acid concentration kept molar high proton conduction P/OH = 0.3, the...

Encapsulation of drugs in nanoparticles can enhance the accumulation of drugs in tumours, reduce toxicity toward healthy tissue, and improve pharmacokinetics compared to administration of free drug. To achieve efficient delivery and release of drugs at the target site, mechanisms of interaction between the nanoparticles and cells and the mechanism of delivery of the encapsulated drug are crucia...

Novel amphiphilic poly-N-vinylpyrrolidone derivatives with different molecular weight of hydrophilic PVP fragment and one secondary di-n-alkyl terminal hydrophobic fragment of different length were synthesized to compare their inclination for formation of nano-scaled micelle-like aggregates in aqueous media with previously studied primary n-alkyl terminated poly-N-vinylpyrrolidones. The behavio...