7-{2-Hydroxy-3-[4-(2-phenoxyethyl)-piperazinyl-1-yl]-propyl}-1,3-di-methyl-3,7-dihydro-1H-purine-2,6-dione dihydrochloride (2), and several of its 8-alkylamino substituted derivatives (11-17) were synthesized and tested for electrocardiographic, antiarrhythmic and hypotensive activity. Also their alpha(1)- and alpha(2)-adrenoreceptor affinities were determined. It was found that compound 2, and...

Case presentation: Male patient, 6 months old, admitted due to seizure associated with severe refractory hypoglycemia. Patient had been experiencing unusual sleepiness for 8 days, and vomiting after feedings. Brain CT showed prominence of the bilateral frontotemporal extra-axial space Sylvian fissures, EEG revealed a slow diffuse moderate disturbance background activity MRI extensive areas diff...

Submit Manuscript | http://medcraveonline.com Abbreviations: HPMC: Hydroxypropyl Methylcellulose; MC: Methylcellulose; PLGA: Poly (Lactide-co-Glycolide); CAP: Cellulose Acetate Phthalate; LCST: Low Critical Solution Temperature; UCST: Upper Critical Solution Temperature; PPO: Polypropylene Oxide; PEO: Polyethylene Oxide; MTA: Methozolamide; PNIPAAm: Poly (N-Isopropylacrylamide); GC: Guluronic A...

Five new phenolic compounds, 4-(beta-D-glucopyranosyloxy)-3,5-dimethoxyphenyl-propanone (8), 3-[5-[(threo) 2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxybenzofuranyl]-propanoic acid (12), 2-[4-(3-hydroxy-1-propenyl)-2,6-dimethoxyphenoxy]-3-hydroxy-3-(4-hydroxy-3,5-dimethoxyphenyl)propyl-beta-D-glucopyranoside (13), 4-[(erythro) 2,3-dihydro-3(hydroxymethyl)-5-(3-hydropropyl)...

In the crystal structure of the title compound, [Zn(C(8)H(9)N(2)O(4))(2)(H(2)O)(2)]·2C(3)H(7)NO, the Zn(II) atom is coordinated by two N,O-bidentate 2-propyl-1H-imidazole-4,5-dicarboxyl-ate anions and two water mol-ecules in a distorted octa-hedral environment. The asymmetric unit consists of one Zn(II) atom located on a center of inversion as well as one anion, one water mol-ecule and one addi...

Five new 1-hydroxy-2-(1-alkyloxymethyl)-9,10-Anthraquinones (9a-e) have been prepared. Selective nitration of 2-methyl-9,10-anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-2-methyl-9,10-anthraquinone in good yield as the key intermediate. Reaction with dimethylsulphate/K2CO3 and subsequen...

The cellular fatty acid composition of Aureispira marina IAM 15389T (JCM 23197T), a gliding bacterium isolated from the coastline Thailand, was re-examined by using standard MIDI method based on alkaline hydrolysis, and two other methods. direct transesterification 5% HCl/methanol or 4 M HCl hydrolysis followed methyl esterification revealed that 2-hydroxy-15-methyl-hexadecanoic (2-OH-iso-C17:0...

The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyri...