UNLABELLED Rheumatoid arthritis is one of the commonest autoimmune diseases. It is a chronic, progressive, systemic inflammatory disorder affecting the synovial joints and typically producing symmetrical arthritis. If left untreated, it leads to joint destruction and thus deformity and disability.In the recent years, advances in molecular biology have led to a variety of new treatment approache...

BACKGROUND Large leg ulcers (LLU) may complicate autoimmune diseases. They pose a therapeutic challenge and are often resistant to treatment. To report three cases of autoimmune diseases complicated with LLU. CASE REPORT Case 1. A 55-year old woman presented with long-standing painful LLU due to mixed connective tissue disease (MCTD). Biopsy from the ulcer edge showed small vessel vasculitis....

Background: RA is an autoimmune disease that presented with chronic inflammation due to synovial hyperplasia, this disease progress through joint destruction. DMARD s is the most usual drug for treating this disease that accompanies with various adverse effects and complications. Aim of this study is to evaluate anti-inflammatory effect of a compound herbaceous drug consist of (ginger, Curcumin...

OBJECTIVE There is no established disease-modifying treatment of xerostomia and xerophthalmia in SS. This retrospective study was performed in order to evaluate the efficacy of HCQ for glandular function, i.e. saliva and tear production. METHODS Fourteen patients with primary SS (pSS) were included (Group A). All patients were anti-Ro and/or -La antibody positive except one. Patients were tre...

Background Previous findings on hydroxychloroquine (HCQ) use and the risk of arrhythmia are contradictory low-level evidence-based results. Additional research is required to evaluate safety profile HCQ in managing rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). Objectives To assess association between initiation incident among newly diagnosed RA SLE patients. Methods All patients...

SARS-CoV-2 has created an agonizing pandemic situation all over the world. The inhibition of main protease (Mpro) by blockage viral replication is considered important drug target to many researchers working discover specific drugs for COVID-19 treatment. Schiff bases being documented possess antimicrobial properties might be investigated as candidate against COVID-19. Bioactivities some symmet...

Abstract The efficacy and safety of Hydroxychloroquine (HCQ) in treating coronavirus disease (COVID-19) is disputed. This systematic review meta-analysis aimed to examine the HCQ addition standard care (SOC) COVID-19. PubMed, Cochrane Library, Embase, Web sciences, medRxiv were searched up March 15, 2021. Clinical studies registry databases also for identifying potential clinical trials. refere...

Macroautophagy and chaperone-mediated autophagy (CMA) represent two major lysosomal degradation processes and often compensate for one another to facilitate cell survival. The aim of this study was to determine whether these autophagy pathways could compensate for one another to promote HCC cell survival in the cirrhotic liver. Analysis of normal liver tissue showed no expression of glypican-3 ...

Felty’s syndrome (FS) is a rare disease defined by the presence of 3 conditions: rheumatoid arthritis (RA), neutropenia, and splenomegaly 1. It has been subdivided into two entities, depending on the presence or absence of large granular lymphocyte (LGL) leukaemia. LGL leukaemia is diagnosed by identifying a T cell clone with typical LGL morphology and phenotype in blood or bone marrow smears. ...

Abstract Background and Aims B-cell activating factor (BAFF) a proliferation-inducing ligand (APRIL) are critical factors in the differentiation longevity maintenance of B-cells pool thereby mediating humoral immunity. BAFF APRIL involved initiating to become self-reactive elevated levels these cytokines detected sera patients with systemic autoimmune diseases. The aim study was estimate role I...