conclusions literature search revealed an increased prevalence of hypothyroidism with secondary hpth from renal failure. although there is increased prevalence of hypothyroid state in secondary hpth from renal failure, the association appears much weaker in primary hpth and again no conclusive pathological relation has been identified between the two endocrine glands. a closer look and perhaps ...

Background: Hyperparathyroidism (HPT) is an endocrine disease characterized by a hypercalcemic state due to hyper secretion of parathyroid hormone. Imaging in parathyroid disease (hyperparathyroidism) is aimed at localizing enlarged parathyroid glands after a biochemical diagnosis of hyperparathyroidism has been made. By precisely identifying the number and location of abnormal parathyroid glan...

We report a Japanese pedigree with familial primary hyperparathyroidism due to a CDC73 mutation. To our knowledge, this is the first report of cinacalcet as a treatment for CDC73-related primary hyperparathyroidism. The proband had severe psychomotor retardation and received laryngotracheal separation surgery. At 19 yr of age, he developed acute pancreatitis. Hypercalcemia (12.2-13.8 mg/dL), el...

Primary hyperparathyroidism is a life-threatening rare disorder. It is seen as a result of neonatal primary hyperparathyroidism, familial hypocalciuric hypercalcemia, increased vitamin D levels and inactivation of calcium sensing receptor mutations. The clinical findings are hypotonia, bone demineralization, hypercalcemia and parathyroid hyperplasia. We present a six-month-old female patient, t...

HYPOTHESIS High-resolution ultrasound and technetium Tc 99m sestamibi scanning can be used for preoperative localization of abnormal parathyroid glands in patients with hyperparathyroidism. DESIGN Ultrasound and sestamibi scanning were performed in patients undergoing neck exploration for hyperparathyroidism. If the 2 scans agreed in identifying a single adenoma, and surgery confirmed the loc...

EDITORIAL SYNOPSIS The possible relationship between hyperparathyroidism and peptic ulcer has stimulated renewed interest in the relationship between calcium and gastric secretion. This study shows that in patients with primary hyperparathyroidism the basal secretion of acid was raised but the augmented histamine secretion was essentially normal. The basal secretion was lowered by parathyroidec...

Severe hyperparathyroidism can affect bone metabolism and be in the origine of multiple brown tumours (generalized osteitis fibrosa cystica). When associated with fibro-ossifying tumours of the jaw, it realizes a rare genetic syndrome referred as Hyperparathyroidism-jaw tumour HPT-JT. We report the case of a patient we treated for HPT-JT, and literature review.

* hyperparathyroidism is a potentially reversible cause of global cognitive decline in the elderly * dementia may occur in hyperparathyroidism with only mildly elevated serum calcium * serial assessment of mental state and serum calcium whilst pharmacologically treating hypercalcaemia is important in establishing a causal link * cognitive improvement may 'lag' behind reduction in serum calcium ...

Severe neonatal primary hyperparathyroidism is a very rare type of primary hyperparathyroidism in pediatrics that might present during infancy with non-specific symptoms. We report an infant who presented with a very high level of calcium, yet responding to simple medications to draw the attention to pediatricians to this disease as early diagnosis and treatment will ameliorate its devastating ...