Background and Objectives: Gastrointestinal polyps are proliferative or neoplastic mucosal lesions. The most important point about these polyps is risk of malignancy of them. This study was performed to determine type and frequency of polyps of gastrointestinal tract in Iranian population according to their locations. Materials and Methods: Totally, 210 patients referred to Rasul-e-Akram Hospi...

Background and study aims  In an optical diagnosis strategy, diminutive polyps that are endoscopically characterized with high confidence are removed without histopathological analysis and distal hyperplastic polyps are left in situ. We evaluated the effectiveness and costs of optical diagnosis. Methods  Using the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model, we simulated b...

Investigating the clinical features and corresponding histomorphologic and molecular profiles of precursor lesions of colorectal cancer in a natural population provides new insights into the nature of colorectal cancer, uncovers new screening markers and establishes new prevention strategies for colorectal cancer. In this study, 4302 patients with at least one colorectal polyp from a large colo...

BACKGROUND/AIMS Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS A total of 269 gastric hyperplastic polyps from 216 patients removed by endoscopic polypectomy (EP) or surgical resection were...

BACKGROUND Hyperplastic polyps are common benign colorectal polyps, and are thought to have little association with malignant tumours in the colorectum. However, several reports suggest that some hyperplastic polyps may develop into colorectal neoplasms. AIM To clarify genetic alterations in colorectal hyperplastic polyps. METHODS Twenty eight colorectal polyps having serrated components we...

AIMS Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative activity and p53 expression in GHPs. METHODS The CD10, MUC2, MUC5AC and MUC6 ex...

A66-year-old Koreanmanwas referred for colonic polypectomy. A colonoscopy performed at another hospital 1 week previously had revealed a large pedunculated polyp with an erythematous surface that was occupying almost the entire lumen in the mid-sigmoid colon (●" Fig.1). The polyp appeared hyperplastic, and no biopsywas performed. The patient was not taking any nonsteroidal anti-inflammatory dru...