Two homologous lightly coupled dinitrophenyl conjugates of poly-L-lysine of differing average molecular sizes were compared with regard to their abilities to elicit in guinea pigs specific delayed hypersensitivity skin reactions, passive cutaneous anaphylaxis, and active Arthus reactions. Equal concentrations by weight (but not equimolar concentrations) of the two conjugates elicited equally in...

Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any react...

BACKGROUND Cross-reactivity between penicillins or cephalosporins and carbapenems is anticipated as all have a beta lactam ring. However, the true incidence of immunoglobulin (Ig)E-mediated cross-reactivity is not known. METHODS A systematic review was conducted to collect and combine all published data on children and adults reported to have a clinical history of IgE-mediated hypersensitivit...

INTRODUCTION Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia therapy. Although hypersensitivity reactions to PEG-ASP occur less frequently than with other formulations, they are not uncommon and have an adverse impact on patient outcomes. Intravenous (IV) administration of PEG-ASP reduces patient pain and anxiety and is being...

BACKGROUND It is hypothesized that because of higher mast cell numbers and mediator release, mastocytosis predisposes patients for systemic immediate-type hypersensitivity reactions to certain drugs including non-steroidal anti-inflammatory drugs (NSAID). OBJECTIVE To clarify whether patients with NSAID hypersensitivity show increased basal serum tryptase levels as sign for underlying mast ce...

Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases of hypersensitivity reactions, in order to systematically summarize the published evidence on preval...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifeste...

BACKGROUND Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system. Epidemiological data related to drug hypersensitivity reactions in our country are scarce. OBJECTIVE To determine the prevalence of drug hypersensitivity in a group of young adults, as well as to identi...

This study was conducted to determine the frequency of sensitization to Aspergillus antigens in 27 patients with perennial rhinitis. Immediate cutaneous reactivity was observed in 7 (26%) patients. In 3 of these 7 patients, hypersensitivity was restricted to Aspergillus antigens alone. One patient had an isolated late cutaneous reaction. Hypersensitivity was observed most commonly with A. flavu...

CASE SUMMARY A 14-year-old, domestic shorthair cat was treated for transient diabetes mellitus for 3 months with glargine insulin, which was discontinued when the diabetes mellitus resolved. Approximately 36 months later the diabetes mellitus recurred and glargine insulin was restarted. Within 2-3 mins of the first injection the cat collapsed, developed profuse vomiting and diarrhea, as well as...