KAY [1930] showed that in certain bone diseases in man the plasma-phosphatase activity is considerably higher than normal. This served as an impetus for investigation into the activity of the enzyme in plasma and tissues under different conditions in man and experimental animals. The literature has been reviewed by Kay [1932] and by Robison [1932], and it is unnecessary to go into it in great d...

IT IS generally recognized that some congenital malformations may be caused by an abnormal environment surrounding the mother in pregnancy. Many experiments have been reported concerning the teratogenesis due to various hypovitaminoses, but there are relatively few reports on teratogenesis resulting from the administration of a large quantity of vitamin. Among the latter, the best known are mal...

Vitamin D toxicity is a rare cause of hypercalcemia and there no consensus on active treatment. Though glucocorticoids can decrease intestinal calcium absorption, increase urinary excretion, reduce levels biologically vitamin metabolites, its use in controversial. Here we present case secondary to hypervitaminosis treated with glucocorticoids. A 77-year-old female history deficiency prior admis...

Hypertrophic osteoarthropathy (HOA) is a bone pathology that can be associated with a number of focal or systemic diseases, particularly those affecting the respiratory system. HOA is characterized by proliferative periostosis of the long bones, especially in their distal and periarticular regions. This report presents a probable case of HOA in the skeleton of an elderly Portuguese male from Év...

Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (Bluebonnet Turmeric Root, 500 mg, Vcap), taken for...