OBJECTIVES An estimated 6%-10% of US adults took a hypnotic drug for poor sleep in 2010. This study extends previous reports associating hypnotics with excess mortality. SETTING A large integrated health system in the USA. DESIGN Longitudinal electronic medical records were extracted for a one-to-two matched cohort survival analysis. SUBJECTS Subjects (mean age 54 years) were 10 529 patie...

Among hypnotic agents that enhance GABAA receptor function, etomidate is unusual because it is selective for beta2/beta3 compared with beta1 subunit-containing GABAA receptors. Mice incorporating an etomidate-insensitive beta2 subunit (beta(2N265S)) revealed that beta2 subunit-containing receptors mediate the enhancement of slow-wave activity (SWA) by etomidate, are required for the sedative, a...

In this study, we investigated the sedative and hypnotic effects of the aqueous extract of Aloe vera on rats. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through analysis...

This study describes the development and preliminary psychometric properties of a scale for measuring hypnotic response in clinical hypnosis sessions. The Hypnotic State Assessment Questionnaire (HSAQ), a brief, multidimensional measure of hypnotic response during clinical sessions of hypnosis, is intended to facilitate supervision of hypnosis trainees and to document subjects' response in clin...