BACKGROUND Under current European Union legislation, two severe hypoglycemic events within 12 months is grounds for driving license withdrawal. The aim of the study reported here was to determine whether fear of such a withdrawal could lead to patients concealing severe hypoglycemia from physicians, which could negatively impact further treatment decisions. METHODS A total of 663 patients wit...

OBJECTIVE Antecedent hypoglycemia reduces hypoglycemic counterregulation and symptoms, thereby provoking the hypoglycemia unawareness syndrome. The effects of antecedent hypoglycemia on hypoglycemia-induced cognitive dysfunction are less well established. RESEARCH DESIGN AND METHODS To determine whether antecedent hypoglycemia also reduces hypoglycemic cognitive dysfunction, we performed step...

Aloe buettneri was evaluated to confirm its hypoglycemic activity. The presence of quinone which seem to leave the hypoglycemic activity. Lyophilisate of A. buettneri leaf (LA) causes hypoglycemia only 2 h after its administration and is linked to the presence of quinone. Glycemia reduction with LA was significantly higher than that of Glibenclamide, the control. Glibenclamide and LA negatively...

Changes in serum free amino acids as a response to ketogenic provocative test were studied in children with a history of ketosis but without hypoglycemia. 1. Of the 17 children who underwent the provocative test, only three showed clinical manifestations. They were among five children who responded to the test and developed hypoglycemia. 2. Hypoglycemic and non-hypoglycemic children differed gr...

Antidiabetic and antihyperlipidemic effect of Hemidesmus indicus Linn.R.root. (HIR) was investigated in rats. Administration of HIR (40 mg/g body weight/day) for four weeks significantly decreased the serum cholesterol, triglyceride, free fatty acids and phospholipid. Four weeks treatment of diabetic rats with HIR (40 mg/g body weight/day) showed significant hypoglycemic effect. Results of the ...

The effects of hypoglycemia on regional cerebral blood flow (rCBF) were studied in awake restrained rats. The rats were divided into three groups consisting of a normoglycemic control group that received only saline, a hypoglycemic group A, which was given insulin 30 min before flow was measured, and a hypoglycemic group B, which was given insulin 90 and 30 min before flow was measured. Regiona...