Oleogum resin (known as guggul) from the guggul tree, Commiphora mukul, found in India, Bangladesh, and Pakistan, has been used to treat various diseases including hyper-cholesterolemia, atherosclerosis, rheumatism, and obesity over several thousands of years. Guggulsterone isolated from guggul has been identified as the bioactive constituent responsible for guggul's therapeutic effects. Since ...

Previous work in this laboratory indicated that sulfursubstituted fatty acid analogues, 1 . lO-bis(carboxymethylthio)decane and alkylthioacetic acid, both non-@-oxidizable compounds, and the @-oxidizable alkylthiopropionic acid (1) caused, to different extents, dase-related hepatomegaly and proliferation of pemxi"es and enhanced pervxisomal fatty acid 8-oxidation. In the present study, treatmen...

Certain phthalate esters and hypolipidemic agents are known to induce morphological and biochemical changes in the liver of rodents, which have been associated with an increased incidence of hepatocellular tumors in these species. There is evidence that hypolipidemic agents do not induce these effects in either subhuman primates or man. The oral and intraperitoneal administration of di(2-ethylh...

agent oriented software engineering (aose) is an emerging field in computer science  and  proposes some systematic ideas for multi agent systems analysis, implementation and maintenance. despite the various methodologies introduced in the agent-oriented software engineering, the main challenges are defects in different aspects of methodologies. according to the defects resulted from weaknesses ...