OBJECTIVE To increase awareness of the incidence of delayed leukoencephalopathy in rehabilitation medicine. SUBJECT A 34-year-old male patient in an inpatient neuro-rehabilitation clinic who developed cognitive, psychological and physical deterioration 33 days after methadone intake. METHODS Clinical follow-up for 7 months, brain imaging with magnetic resonance imaging and computed tomograp...

Abstract Progressive multifocal leukoencephalopathy (PML) is a serious and often lethal demyelinating disease of the brain that develops almost exclusively in patients with severe immunosuppression. The caused by reactivation latent polyoma JC virus (JCV). PML occurs rarely non-hematologic malignancies, this report, authors present an uncommon case rapidly progressing, fatal patient advanced pr...

The records of 415 patients who received allogeneic marrow transplants for acute leukemia were reviewed to assess the risk of central nervous system (CNS) relapse and leukoencephalopathy after marrow transplantation. The Kaplan-Meier estimates of the probability of CNS relapse posttransplant were 13% for patients with acute lymphoblastic leukemia (ALL) and 2% for patients with acute nonlymphobl...