Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of Ak-E...

Background and Purpose—The risk of intracranial aneurysm (IA) rupture in asymptomatic members of families who have multiple affected individuals is not known. Methods—First-degree unaffected relatives of those with a familial history of IA who had a history of smoking or hypertension but no known IA were offered cerebral MR angiography (MRA) and followed yearly as part of a National Institute o...

The use of type Ia supernovae (SNe Ia) as cosmological standard candles is fundamental in modern observational cosmology. In this letter, we derive a simple empirical photometric redshift estimator for SNe Ia using a training set of SNe Ia with multiband (griz) light-curves and spectroscopic redshifts obtained by the Supernova Legacy Survey (SNLS). This estimator is analytical and model-indepen...

H-2 antigens are expressed in substantial amounts of murine blood platelets (for H-2 antigenic content 1 lymphocyte approximately 50 platelets) whereas Ia antigens are probably not expressed at all (minimal Ia antigenic content more than 35 times lower than for H-2). This property of blood platelets makes them very useful for the selective absorption of anti-H-2 antibodies from complex sera and...

Submillisecond mixing experiments and tryptophan fluorescence spectroscopy are used to address two questions raised in earlier stopped-flow studies of the folding and unfolding kinetics of sperm whale apomyoglobin. A study of the pH 4 folding intermediate (I) revealed, surprisingly, that its folding and unfolding kinetics are measurable and fit the two-state model except for a possible burst ph...

The identity of the progenitor systems of type-Ia supernovae (SNe Ia) is a major unsolved problem in astrophysics. SN Ia rates are providing some striking clues. We review the basics of SN rate measurement, preach about some sins of SN rate measurement and analysis, and illustrate one of these sins with an analogy about Martian scientists. We review the recent progress in measuring SN Ia rates ...

BACKGROUND The anatomical complexity of the horse's head limits the abilities of radiography. Computed tomography (CT) in combination with contrast enhanced CT is used more often for diagnosing various head pathology in horses. The objective of this study was to compare intravenous and intra-arterial contrast-enhancement techniques and describe normal and abnormal contrast enhancement in the ho...

The amount of Ni produced in type Ia supernova (SN Ia) explosion is probably the most important physical parameter underlying the observed correlation of SN Ia luminosities with their light curves. Based on an empirical relation between the Ni mass and the light curve parameter △m15, we obtained rough estimates of the Ni mass for a large sample of nearby SNe Ia with the aim of exploring the div...

The initiation of many antigen-specific, T-dependent immune responses requires the participation of accessory cells that express Ia antigens (1, 2). Recent evidence indicates that the Ia antigen expression of macrophages, a principle class of accessory cells, is regulated by lymphokines: Ste inman et al. (3) have reported that culture supernatants of Trypanosoma cruzi-activated spleen cells enh...

Author details Department of Occupational and Environmental Health, University of Iowa, 105 S. River St. #318, Iowa City, IA 52242, USA. Injury Prevention Research Center, University of Iowa, Iowa City, IA, USA. Cedar Rapids Community School District, Cedar Rapids, IA, USA. School of Social Work, University of Southern California, Los Angeles, CA, USA. Department of Biostatistics, University of...