BACKGROUND AND PURPOSE Small renal tumors are often serendipitously detected during the screening of patients for renal or other disease entities. Rather than perform a radical or partial nephrectomy for these diminutive lesions, several centers have begun to explore a variety of ablative energy sources that could be applied directly via a percutaneously placed needle-like probe. To evaluate th...

Matrix metalloproteinases (MMPs) are a family of zinc-dependent enzymes which take part in the sophisticated coordination of extracellular matrix (ECM) synthesis and breakdown. Together they can cleave essentially all matrix proteins. Degradation of connective tissue is required both in normal physiologic processes and in pathologic tissue remodeling such as cancer. The aim of this study was to...

Sir: H formation is one of the most common complications in rhytidectomy surgery. Surgeons employ strict postoperative blood pressure protocols and special wraps and drains to try to prevent hematomas from developing and causing skin necrosis. Despite these efforts, hematoma rates range from 1% to 15%.1,2 Tranexamic acid (TXA) is a fibrinolytic inhibitor developed in the 1960s and is primarily ...

Introduction: Major depression is the most common psychiatric disorder. Neuroimaging studies with quantitative evaluation of anatomical structures and physiological parameters may provide increasing knowledge on the pathophysiology of the disease (1). Automatic measurements of cortical thickness in high resolution structural MRI can be performed by reconstruction of the cortical boundaries usin...

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Multiple genetic alterations are common in cancers including those of the breast. The mechanisms leading to these alterations such as point mutations, gene amplifications, deletions and replication error are often associated with frequent and consistent loss of heterozygosity (LOH) or microsatellite instability (MSI). Several cytological and molecular studies have shown high frequency loss of g...

Hypercholesterolemia Increases Circulating Endothelial Progenitor Cell Population in Adults To the Editor: Hypercholesterolemia represents a major cardiovascular risk factor because of its ability to promote and sustain proatherogenic inflammation of vascular wall.1 A reduction of number and activity of bone marrow–derived endothelial progenitor cells (EPCs) could participate in the development...

The Center for Transportation Research (CTR) Vehicle Systems team modified a Nissan CK-2 Continuously Variable Transmission (CVT) for a diesel hybrid powertrain application. Mechanical and electrical modifications were made to the CVT, both internal and external to the transmission. The goal of this experiment was to investigate and demonstrate the potential of CVT for diesel engines hybrid ele...

Key Findings▪The case describes use of Focal Pulsed Field Electroporation (F-PFE) to ablate PVCs originating in the RVOT-LVOT-RCC zone▪F-PFE electroporation was carried out using low medium energy delivery preceded by intravenous nitrates prevent coronary spasm and under real time ICE-imaging.▪Electroporation applied solely RVOT safe without any short- or long-term adverse events▪48 h Holter fo...