The contribution of polymorphic markers rs2234663 (VNTR) and rs419598 (c.2008T>C) the IL1RN gene to predisposition development arterial hypertension among population Karelia was studied. occurrence alleles genotypes for these almost same in group healthy people patients with (χ2 = 0.178, p 0.67; χ2 0.540, 0.76; 0.01, 0.93, 1.68, 0.43, respectively rs419598). level IL-1β IL-1α plasma did not ...

Abstract Adhesion of T cells to antigen presenting is mediated by the TCR–MHCp and LFA1–ICAM1 protein complexes. These intercellular complexes segregate form characteristic special patterns in cell contact zone. Previous studies have attempted explain mechanisms formation these patterns. While emphasis has been put on membrane elasticity active cytoskeletal transport, it remains unclear whether...

The observed pattern of neutrino mixing may be the result of a 2-3( μ−τ) symmetry in the leptonic sector. We consider a two Higgs doublet model with a 2-3 symmetry in the down type quark and the charged lepton sector. The breaking of the 2-3 symmetry by the strange quark mass and the muon mass leads to FCNC in the quark sector and the charged lepton sector that are suppressed by ms mb and mμ mτ...

We investigated a general framework of the Standard Model with two Higgs doublets (2HDSM) with suppressed flavor-changing neutral currents (FCNC’s). Loop-induced FCNC (and CP-violating) effects, when confronted with experimental constraints for theK-K̄, B-B̄ and D-D̄ mixing and for the (b → sγ) decay, provide us with constraints on the values of the dominant Yukawa couplings of the charged Higgs, ...

Lymphocyte function-associated antigen 1 (LFA-1) plays important roles in immune cell adhesion, trafficking, and activation and is a therapeutic target for the treatment of multiple autoimmune diseases. Efalizumab is one of the most efficacious antibody drugs for treating psoriasis, a very common skin disease, through inhibition of the binding of LFA-1 to the ligand intercellular adhesion molec...

We consider FCNC and CP violating processes mediated by gluino exchange in generalized supersymmetric theories. We present the constraints on flavour (F) changing squark mass terms at the electroweak energy scale, focusing our analysis on ∆F = 2 transitions. Results are also given for ∆F = 1 CP conserving processes both in the hadronic and leptonic sectors, while we limit ourselves to some rema...

Glycosaminoglycans (GAGs) are ubiquitously present at the cell surface and in extracellular matrix, and crucial for matrix assembly, cell-cell and cell-matrix interactions. The supramolecular presentation of GAG chains, along with other matrix components, is likely to be functionally important but remains challenging to control and to characterize, both in vivo and in vitro. We present a method...