Many gram-negative pathogens use a type IV secretion system (T4SS) to deliver effector proteins into eukaryotic host cells. The fidelity of protein translocation depends on the efficient recognition of effector proteins by the T4SS. Legionella pneumophila delivers a large number of effector proteins into eukaryotic cells using the Dot/Icm T4SS. How the Dot/Icm system is able to recognize and co...

The quest to reduce the informational asymmetry between tax authorities and taxpayers, increasing compliance, was one of main intentions with implementation SPED in Brazil. Thus, need arose understand its efficiency, as well impact on revenue. In this context, study focused assessing whether had an ICMS gap, from perspective auditors, using PLS-SEM structural equation modeling technique. As a r...

Resumo Este estudo analisa o impacto da mudança lei cota-parte do ICMS na acessibilidade educacional no curto e longo prazo. Para isso, utilizou-se um modelo de mínimos quadrados com efeitos fixos em dados corte transversal. Encontrou-se que esta política pública amplia percentual matrículas pré-escola Ensino Fundamental. Um aumento 1 ponto variação aumenta 0,0036 0,0021 a prazo, respectivament...

While a substantial literature demonstrates the effect of differential experience on development of mammalian sensory cortices and plasticity of adult motor cortex, characterization of differential experience on the functional development of motor cortex is meager. We first determined when forelimb movement representations (motor maps) could be detected in rats during postnatal development and ...