background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cyt...

Theoretical aspects of x-ray standing wave method for investigation of the real structure of crystals are considered in this review paper. Starting from the general approach of the secondary radiation yield from deformed crystals this theory is applied to different concreate cases. Various models of deformed crystals like: bicrystal model, multilayer model, crystals with extended deformation fi...

Abstract Background and Aims Cardiopulmonary bypass (CPB) may trigger organs damage, including kidney injury, due to a massive cytokine release. In this observational, prospective study, we have analyzed the possible impact of chronic treatment with ACE-Inhibitors (ACE-I) on inflammatory response renal function after CPB. Method Sixty-nine patients undergoing major cardiac surgery CPB were enro...

Interleukin-3 (IL-31 stimulates colony formation of multiple lineages of hematopoietic cells. Bone marrow cells of A/J mice are nonresponsive to IL-3, and this observation has recently been correlated with aberrant mRNA splicing and impaired expression of the IL-3 receptor a subunit (IL-BRa). a binding component of the high-affinity receptors. We examined the IL-3Ra gene in 27 inbred mouse stra...

Systemic sclerosis (SSc) is a chronic disease characterized by microvasculopathy, autoantibodies (autoAbs), and fibrosis. The pathogenesis of the incompletely understood. Microvasculopathy autoAbs appear very early in process. AutoAbs, such as those directed against DNA topoisomerase I (Topo I), are specific associated with manifestations, indicate activation adaptive immune system. B cells inv...

Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring anti-inflammatory antagonist of the proinflammatory cytokine IL-1, a critical factor in many inflammatory diseases. The aim of the present study was to investigate the role of IL-1ra in hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Serum cytokine concentrations were measured using a Q-Plex array in 31 patients w...

© 2015 The Authors. doi: 10.2340/00015555-2104 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Primary localized cutaneous amyloidosis (PLCA; MIM 105250) is a chronic itchy skin disorder associated with amyloid deposits in the superficial dermis (1). Clinically, most skin lesions comprise small, flat-topped papules (lichen amyloidosis) or brown-grey macules (macular amyloi...

INTRODUCTION According to available data, pruritus is a common symptom of psoriasis, however its characteristics and pathogenesis are not clearly understood. AIM The main aim of this study was to assess itching sensation among patients suffering from psoriasis, including its incidence and severity. All factors triggering and worsening pruritic symptoms were also carefully analyzed. The author...

IntroductionAccurate diagnosis of chikungunya (CHIK) is essential for effective disease management and surveillance. In a cohort febrile Congolese patients, available diagnostic methods widely used in CHIK were evaluated. addition, plasma cytokines quantified patients those coinfected with malaria compared healthy controls.MethodsBetween June November 2019, total 107 suspected subjected to diff...