نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

2012
Huy A Tran Tracey L Jones Elizabeth A Ianna Robert A Gibson Glenn E M Reeves

BACKGROUND Single nucleotide polymorphism in the interleukin28B (IL28B) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic hepatitis C. Similarly, thyroid disease (TD) occurring during treatment confer an improved sustained virologic response (SVR). OBJECTIVES To determine the role of IL28B genotype...

Journal: :hepatitis monthly 0
yoshio aizawa department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan; department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan , +81-336032111 noritomo shimada department of gastroenterology and hepatology, shinmatsudo chuo general hospital, chiba, japan hiroshi abe department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan nobuyoshi seki department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan yuta aida department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan haruya ishiguro department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan

conclusions examination of the fasting lipid profile has clinical importance in predicting the efficacy of peg-ifn-α-2b plus rbv combination therapy for patients with hcv g1b even after the discovery of the il28 genotype as a potent predictive factor. objectives to re-examine the significance of lipoprotein profiles on virological response to peg-ifn plus rbv combination therapy in patients wit...

2016
Farah Bokharaei-Salim Mostafa Salehi-Vaziri Farzin Sadeghi Maryam Esghaei Seyed Hamidreza Monavari Seyed Moayed Alavian Shahin Fakhim Hossein Keyvani

BACKGROUND The hepatitis C virus (HCV) infection has been identified as a leading cause of progressive liver diseases worldwide. Despite new treatment strategies, pegylated interferon alfa-2a (Peg-IFNα-2a), in combination with ribavirin (RBV), still represents the gold standard of therapy for hepatitis C in developing countries. OBJECTIVES The aim of this study was to investigate the associat...

Journal: :hepatitis monthly 0
huy a tran xu~ o~og{eserw}koloohezwowe~ jo{~i un e~okowtivao number 1, hunter mail region centre, australia +61-249214005, [email protected]; xu~ o~og{eserw}koloohezwowe~ jo{~i un

background: single nucleotide polymorphism in the interleukin28b (il28b) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic hepatitis c. similarly, thyroid disease (td) occurring during treatment confer an improved sustained virologic response (svr). objectives: to determine the role of il28b genotype...

Journal: :Alimentary pharmacology & therapeutics 2012
Y Chen H-X Xu L-J Wang X-X Liu R I Mahato Y-R Zhao

BACKGROUND Interleukin (IL) 28B single nucleotide polymorphisms can predict sustained virological response (SVR) in hepatitis C virus (HCV) patients following pegylated interferon-alpha (PEG IFN-α) and ribavirin treatment. AIM To design a meta-analysis to determine IL28B genotypes', rs12979860 CC and rs8099917 TT, correlation with SVR in PEG IFN-α/ribavirin-treated HCV patients. METHODS Met...

2013
Yoshio Aizawa Noritomo Shimada Hiroshi Abe Nobuyoshi Seki Yuta Aida Haruya Ishiguro Makiko Ika Keizo Kato Akihito Tsubota

BACKGROUND Abnormal serum lipid profiles have been noted in patients with chronic hepatitis C virus (HCV) infection. Moreover, many reports suggest that serum lipoprotein profiles are more profoundly distorted in patients with HCV G1b infection who have an unfavorable response to pegylated interferon (peg-IFN) plus ribavirin (RBV) combination therapy. However, after the discovery of single nucl...

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