Expression of the interleukin-2 receptor alpha-(IL-2Ralpha-), IL-2Rbeta-, and the recently identified IL-2Rgamma-chain was examined on a wide range of cells of myeloid origin including neutrophils, monocytes, normal bone marrow-derived myeloid progenitors enriched for CD34+ cells, bone marrow blasts obtained from acute myelogenous leukemia (AML) patients, and permanent myeloid leukemia cell lin...

Multiple sclerosis (MS) is an autoimmune disease characterized by infiltration of pathogenic immune cells in the CNS resulting in destruction of the myelin sheath and surrounding axons. We and others have previously measured the frequency of human myelin-reactive T cells in peripheral blood. Using T cell cloning techniques, a modest increase in the frequency of myelin-reactive T cells in patien...

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer in the world. Tobacco chewing is implicated with most of the cases of HNSCC but this type of cancer is increasing in non-tobacco chewers as well. This study was instigated to provide comprehensive variant and gene-level data in HNSCC subjects of the Indian population and fill the gap in the literature on comp...

Primary immunodeficiency disorders (PIDs) are inborn errors of the immune system. There are over 150 types of PIDs and because of their rarity, multi-center collaboration for pooled data analysis and molecular studies is important to gain meaningful insights about the phenotypic and genetic diversities of PIDs. Since 2001, our unit established collaboration with 30 pediatric centers in China an...

BACKGROUND The soluble form of the interleukin 7 receptor (sIL-7R) is produced by fibroblasts after stimulation with proinflammatory cytokines. Increased sIL-7R serum and synovial fluid levels were recently demonstrated in patients with rheumatoid arthritis. OBJECTIVES To investigate whether sIL-7R production is dysregulated in systemic lupus erythematosus (SLE), and whether this correlates w...

Two types of T cells, alphabeta and gammadelta, develop in vertebrates. How these two T cell lineages arise from a common thymic T progenitor is poorly understood. Differentiation of alphabeta lineage T cells requires the surrogate alpha chain (pTalpha), which associates with the T cell receptor (TCR) beta chain to form the pre-TCR. gammadelta lineage development does not appear to involve an o...

Background Rheumatoid arthritis (RA) is a complex disease, caused by combination of genetic, epigenetic and environmental factors common to other related autoimmune diseases including Multiple Sclerosis (MS) Systemic Lupus Erythematosus (SLE) [1]. Using state the art Bioinformatics tools we are able formulate an ensemble associated components (genomic grammar) for each disease distinguish impor...

Background: Modes of action DMARDs (disease-modifying antirheumatic drugs) in rheumatoid arthritis (RA) are not completely understood at the level synovium. Studying treatment-induced modifications RA synovial tissue can provide unique insights into pathways modulated downstream different DMARDs. Objectives: Our goal was to assess histological and transcriptomic effects Abatacept (ABA) on synov...

CRLF2, the gene encoding the cytokine receptorlike factor 2, is located in the pseudoautosomal region 1 (PAR1) of both sex chromosomes. Its aberrant expression is the defining feature of an otherwise genetically heterogeneous relapse-prone group of B cell precursor acute lymphoblastic leukemias (BCP ALL) in children and adolescents. The two most common causative genetic defects are, first, an i...