Nanoformulations can play an important role in the improvement of anticancer drug therapies. The bioavailability sorafenib, which is exclusively applied treatment unresectable hepatocellular carcinoma, may be increased by its incorporation a biocompatible nanoparticulate matrix that capable targeting and controlling release. copolymers ε-caprolactone are emerging biodegradable compounds for del...

In recent years, the development and deployment of nano-immobilized lipases, as robust biocatalysts, has appeared a promising alternative for biodiesel production. There is significant hike in using nano-sized support matrices enzyme-based biotransformation bioprocesses with ever-increasing scientific awareness nanotechnological advancement. Several nano-scale materials include magnetic non-mag...

Green and effective synthesis of flavor esters is a long-term interest in food, cosmetic pharmaceutical industries. Here, an immobilized lipase microarray was prepared by immobilizing CSL on hydrophobically modified ordered mesoporous silicon ([email protected]8) for the enzymatic production cinnamic with different flavors. The results showed that [email protected]8, immobilization capacity 249...

The kinetics of the transesterification of phosphatidylcholine (PC) with α-linolenic acid ethyl ester (ALAEE) catalyzed by immobilized lipase in hexane was studied. The reaction proceeded via a Ping-Ping Bi-Bi mechanism without inhibition by both the substrates at various concentrations tested. A reaction kinetic model was proposed with the experimental data. The kinetic constants of the model ...

A twin inhibition is observed for the esterification reaction between ethanol and isovaleric acid using immobilized lipase from Rhizomucor miehei in hexane and in mixed solvent system. The observed bi-substrate inhibition pattern follows a Ping-Pong Bi-Bi mechanism with dead-end inhibition of enzyme by both the substrates. An increase in Km value for alcohol in mixed solvent (0.645 M) than in h...

The immobilization of Rhizopus oryzae lipase (RoL) by hydrophobic adsorption on polypropylene supports with additives was investigated. Additives such as hen egg albumin, sodium caseinate and CAVAMAX® W6 were used to coat the support during where immobilized RoL coated compared those noncoated support. Following immobilization, catalytic activity characterized based different temperatures pH. w...

In order to obtain phosphatidylcholine (PC) with higher amount of oleic acid, the interesterification between soybean PC and Camellia oleifera oil (COO) rich in oleic acid catalyzed by lipase was studied in hexane. For this aim three commercially available immobilized lipases (Novozym 435, Lipozyme TLIM and Lipozyme RMIM) were assayed and Novozym 435 was finally selected for further optimizatio...

Magnetic silica aerogel in hydrophobic and hydrophilic forms were used as support to immobilize Candida rugosa lipase by adsorption method. Response surface methodology (RSM) was employed to study the effects of the three most important immobilization parameters, namely enzyme/support ratio (0.3-0.5, w/w), immobilization time (60-120 min) and alcohol percentage (20-40, %v/v) on the specific act...

The synthesis of sugar fatty acid esters (SFAEs) from lignocellulosic biomass and oleic (C18:1) was catalyzed by immobilized-stabilized derivatives Candida antarctica lipase B in a methyl ethyl ketone medium. After steam-explosion pretreatment mixed hardwoods enzymatic hydrolysis at 15%wt solids, xylose glucose were purified/concentrated to mass ratio ~3 1. These sugars superior commercial as t...

The release of omega-3 fatty acids by the mild enzymatic hydrolysis of sardine oil was studied. The derivatives of different lipases physically adsorbed on hydrophobic porous supports Hydrophobic Lipase Derivatives (HLD) were tested. These immobilized lipases can only hydrolyze oil molecules partitioned into the aqueous phase of a biphasic reaction system. HLD biocatalysts were compared to othe...