The involvement of immune complexes during experimental arthritis in induction of metalloproteinases (MMP)-induced neoepitopes in aggrecan in cartilage, as well as the role of stromelysin-1 (SLN-1) in the induction of this neoepitope, was investigated. Passive immune complex arthritis was induced, and generation of the MMP-specific cleavage product (VDIPEN) was studied by immunolocalization. Th...

Autoimmune diseases are diseases associated with dysfunction of the human immune system, which perceives its own tissues as foreign and damaging it. Such diseases are called systemic, because, as a rule, affects the whole system or even the entire body. The incidence of autoimmune rheumatic diseases and their prevalence is sufficiently large in the world. The most common among the adult populat...

Autoimmune diseases are diseases associated with dysfunction of the human immune system, which perceives its own tissues as foreign and damaging it. Such diseases are called systemic, because, as a rule, affects the whole system or even the entire body. The incidence of autoimmune rheumatic diseases and their prevalence is sufficiently large in the world. The most common among the adult populat...

Asingle intraperitoneal injection of bacterial cell walls derived from groupA streptococci (SCW)' into susceptible rats results in the development of acute and chronic erosive polyarthritis (1, 2) . The pathology of the lesion leading to joint destruction has been shown to be aT cell-dependent, cell-mediated response to the deposition of the group A streptococcal peptidoglycan-polysaccharide po...

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Author's response to reviews: Please find enclosed our case-report entitled « Etanercept may induce neurosarcoidosis in a patient treated for rheumatoid arthritis» that we wish to submit to BMC Neurology.-This is an exceptional case of neurosarcoidosis occurring in a seropositive rheumatoid arthritis patient treated by etanercept.-This case raises the issue of the imputability of etanercept in ...

Conventional beliefs and some publications, had in the past, asserted that systemic auto immune diseases such as inflammatory arthritis, connective tissue diseases and vasculitis are rare. Many of such reports had been hospital based and were not based on the ACR criteria. Rheumatoid arthritis was reported as being rare, especially among West Africans; so also Systemic Lupus Erythematosus, Scle...

Juvenile idiopathic arthritis (JIA) reflects a group of clinically heterogeneous, autoimmune disorders in children characterized by chronic arthritis and hallmarked by elevated levels of circulating immune complexes (CICs) and associated complement activation by-products in their sera. Immune complexes (ICs) have been detected in patients' sera with JIA utilizing a variety of methods, including...

Regulatory T (Treg) cells have emerged as a distinct subset of lymphocytes that are responsible for limiting immune responses and avoiding pathologic autoimmunity. Evidence is accumulating that defects in Treg function are important in immune-mediated diseases such as rheumatoid arthritis (RA). We discuss herein the biology of Treg cells and emphasize what is known about Treg dysfunction in RA.

Azathioprine, 6-MP and Methotrexate were developed for cancer chemotherapy, but when used in small doses, they can be helpful for treating chronic inflammatory diseases such as IBD and some forms of arthritis. These are medications that reduce (suppress) the activity of the immune system by suppressing the bone marrow where immune cells are formed. These medications are called immunosuppressive...