A large number of multicomponent vaccine candidates are currently in clinical evaluation, many of which also include the HIV-1 Tat protein, an important regulatory protein of the virus. However, whether Tat, a known immune effector molecule with a well-conserved sequence among different HIV subtypes, affects the immune response to a coimmunogen is not well understood. In this study, using a bic...

BACKGROUND Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in de novo guanine nucleotide synthesis and is implicated in cell cycle control. Inhibition of this enzyme is associated with immunosuppressive, antiviral, and antitumor activity. IMPDH basal activity increases after initiation of immunosuppressive therapy. METHODS A real-time reverse-transcription PCR ass...

Pemphigus is rare in children, only 71 cases have been reported in literature. We report 2 cases of pemphigus vulgaris (13 and 15 years old) among 147 cases of pemphigus from Khouzestan who were admitted to the Department of Dermatology, Ahwaz Medical University between 1989-2001. The basis of diagnosis was clinical and histopathological findings in each patient. One patient was treated only wi...

Bovine seminal ribonuclease (BS RNase) displays immunosuppressive and antitumor activities on mammalian cells, whereas bovine pancreatic ribonuclease (RNase A) is not cytotoxic. To learn more about the mechanism of BS RNase cytotoxicity, various mutants and hybrid proteins were prepared. A series of RNase A variants substituted with amino acid residues from BS RNase were prepared. Concerning qu...

aerial parts of salvia mirzayanii was extracted with methanol. methanol extract was suspended in water and defatted with petroleum ether. the defatted part was then partitioned between ethyl acetate and water. the ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...

introduction: ebv is categorized as herpesviridans and by nature is a lymph crypto virus. studies have demonstrated that ebv will infect 80 to 90 percent of patients during the first year and there is a close relation between kidney malfunction and ebv infection. reactivation of the virus excites the immune system, and ultimately leads to rejection of kidney. the purpose of this study was to de...