The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean BMI 23.9±3.2 kg/m(2)) underwent an oral glucose tolerance test (OGTT). Of thes...

BACKGROUND Impaired fasting or glucose tolerance and/or diabetes can occur with hypertension, which theoretically predicts a worse cardiovascular risk profile, and consequently requires intensive cardiovascular risk management. OBJECTIVES To characterise the frequency of the occurrence of conventional cardiovascular risk factors among hypertensive subjects with impaired fasting blood glucose....

OBJECTIVE To report the age- and sex-specific prevalences of diabetes and impaired glucose regulation (IGR) according to the revised 1999 World Health Organization criteria for diabetes in Europe. RESEARCH DESIGN AND METHODS A total of 13 studies from nine European countries with 7,680 men and 9,251 women aged 30-89 years were included in the data analysis. RESULTS In most of the study popu...

Background & Aims: The aim of this study was to estimate the prevalence and risk factors for diabetes, pre-diabetes and metabolic syndrome in first-degree relatives(FDRs) of patients with type 2 diabetes. Methods: In a cross-sectional study between 2003 and 2005, 3228 of first-degree relatives of patients with type 2 diabetes (841 men and 2387 women) from Isfahan Endocrine and Metabolism Resear...