Sirtuins family are a Nicotinamide Adenine Dinucleotide (NAD+) dependent histone deacetylase enzyme. have been implicated in the pathogenesis of various diseases including cancer, neurological disorders and metabolic syndromes, hence sirtuins appointed as promising therapeutic target for diseases, by regulating its activity small molecules modulators. The indole containing selisistat (EX-527) d...

Dengue is a vector-borne viral disease caused by Flavivirus. Current treatment and medicine are inadequate to eradicate the vector mosquitoes or prevent disease. Traditional healers have remedies for almost all ailments using natural products plants. The well-known medicinal plant Euphorbia hirta L. one of herbs conventionally used anti-dengue even if active compound responsible exact activity ...

Abstract Fifteen new benzothiophene-based compounds were designed, synthesized, and evaluated as potential anti-Alzheimer agents. Most of the synthesized exhibited remarkable AChE inhibitory activity effectively inhibited self-mediated ?-amyloid protein in vitro. Compound 3g (IC 50 = 72.488 ± 3.69 ?M) showed a significant effect exceeding that donepezil 87.414 4.46 ?M). Furthermore, compound 3j...

The epidermal growth factor receptor (EGFR) belongs to the HER/erbB tyrosine kinase (RTK) family, serving as a crucial target for cancer treatment. Anti-EGFR drugs, used primary treatment patients with advanced EGFR gene mutations such T790M, C797S, and L858R, have shown greater efficacy safety compared standard chemotherapy. This study aimed screen alkaloid compounds anticancer activity, extra...