background: acyclovir (acv), a synthetic purine nucleoside analogue, is known to be toxic to gonads. objective: the current study evaluated cytotoxicity of acv on histopathological changes in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats. materials and methods: animals were divided into five groups. one group served as control and one group served as co...

Cinnamon has many therapeutic effects, such as its impact the increase of sexual ability. This experiment was conducted to determine the effect of cinnamon extract on spermatogenesis and hormonal axis of pituitary gonad in mice. The animals used in this study are male adult mice (weighing about 30-34 g and 9-10 weeks old). Cinnamon was purchased from one of the most valid shops in Jahrom and th...

BACKGROUND Despite harmful drinking causing a significant burden on global health, there is a large treatment gap, especially in low- and middle-income countries. A major barrier to care is the lack of adequately skilled human resources to deliver contextually appropriate treatments. This paper describes the systematic process used to develop Counselling for Alcohol Problems (CAP), a brief psyc...

background: from the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. radiation protection concepts and philosophy have been evolving over the past several decades. materials and methods: the radioprotective of effect of aloe vera leaf extract (1000 mg /kg b.wt. orally for 15 consecutive days) has been studied against 6 gy of gamma radiation in ...

Backgrounds: A straight-forward way to identify whether a drug or environmental chemical can be harmful to unborn baby is to evaluate its effect on laboratory animals. All invivo methods need large number of animal and are therefore time consuming and expensive. However, the thousands of chemicals in need of testing, to reduce the spending of live animals, an assortment of in vitro assays has ...

decreased cardiac responsiveness to adrenergic stimulation has been observed in cholestatic liver disease, but the cause remains unclear. previous reports have suggested that nitric oxide overproduction might have a role in cholestasis-induced bradycardia via inhibition of l-type calcium channels. in the present study, the digoxin has been used to increase cardiac ca2+ transient in male sprague...

introduction: different vasoactive factors can modulate cardiovascular adaptation to hemorrhagic shock including nitric oxide (no). in this study we investigated the effect of  the no synthase inhibitor for treatment of  decompensated hemorrhagic shock in normotensive and hypertensive rats. methods: twenty‑four male wistar rats were divided into two groups: the normotensive and hypertensive gro...

Cimetidine is effective drugs on male reproductive system by its effect semen characteristic or parameters such as sperm motility, morphology and count, also cimetidine sexual hormones, were testosterone, FSH LH. In this investigation, 20 rats randomly classified into two groups, Control group(G1): This group contain 10 receiving normal saline group( G2): 100mg/kg. B.W. from group, during the p...