The CYP2C19*2 loss-of-function allele is associated with reduced generation of active metabolites of clopidogrel. However, meta-analyses have supported or discounted the impact of genotype on adverse cardiovascular outcomes during clopidogrel therapy, depending on studies included in the analysis. Here we review these data and conclude that evidence supports a differential effect of genotype on...

BACKGROUND AND OBJECTIVES: Methadone is a synthetic long-duration opioid with pharmacological properties qualitatively similar to morphine for its action on μ-opioid receptor. It is primarily used to treat cancer pain refractory to morphine. This study aimed at presenting a review of this drug with focus on pharmacokinetic and pharmacodynamic aspects, in addition to its clinical indication. CON...

A 74yearold dialysisdependent male with a history of diabetes received annual health checkups with an electrocardiogram (ECG; ECG1550, Nihon Kohden, Tokyo, Japan) without showing any symptoms. His ECG revealed no significant changes compared with his previous electrocardiograms. However, the computer revealed his heart rate to be 218/min, twice the true heart rate of 108/ min. This result was c...

Intentional replantation can be used for root canal re-treatment when other methods are deemed unsuitable. This procedure is based on the approach used to obtain good clinical outcomes for replantation of an avulsed tooth. The key to a successful procedure is atraumatic extraction and replacement in the socket without damage to the periodontal ligament. This case series presents the long-term o...

Now a days the object tracking is an important task within the field of computer vision. Also the increasing need for automated video analysis has generated a great deal of interest in object tracking algorithms. Therefore in this paper shows a system, which will automatically recognize, track and destroy the intruding object that will be captured by camera. This system can be used in the milit...

Moving Target Defense (MTD) has emerged as a game changer in the security landscape, as it can create asymmetric uncertainty favoring the defender. Despite the significant work done in this area and the many different techniques that have been proposed, MTD has not yet gained widespread adoption due to several limitations. Specifically, interactions between multiple techniques have not been stu...

Incremental search algorithms, such as Generalized FringeRetrieving A* and D* Lite, reuse search trees from previous searches to speed up the current search and thus often find cost-minimal paths for series of similar search problems faster than by solving each search problem from scratch. However, existing incremental search algorithms have limitations. For example, D* Lite is slow on moving t...

A Moving Target Defense (MTD)-enabled system is one which can dynamically and rapidly change its properties and code such that the attackers do not have sufficient time to exploit it. Although a variety of MTD systems have been proposed, fewwork has focused on assessing the relative cost-effectiveness of differentMTD approaches. In this paper, based on a generic MTD theory, we propose five gene...

We study network centrality based on dynamic influence propagation models in social networks. To illustrate our integrated mathematical-algorithmic approach for understanding the fundamental interplay between dynamic influence processes and static network structures, we focus on two basic centrality measures: (a) Single Node Influence (SNI) centrality, which measures each node’s significance by...

Purpose Urban consolidation centres (UCCs) are often conceived to improve services in retail stores and potentially reduce costs. However, few studies have examined how retail stores perceive the services a UCC could provide. The purpose of this article is to explore retail stores’ potential demands for different services that a UCC could provide in order to foster the development and implement...