نتایج جستجو برای: induced allergic asthma
تعداد نتایج: 1061188 فیلتر نتایج به سال:
Generalized underrepresentation of IFNhas been implicated in the development of allergic asthma. However, the role of local IFNin the lung during the development of this disease has not been completely elucidated. We studied the influence of local pulmonary IFNexpression on the development of allergen-induced lung inflammation. To restrict our analysis to IFNexpression in the lung and to exclud...
Asthma is one of the most common of medical illnesses and is treated in part by drugs that activate the beta-2-adrenoceptor (β2-AR) to dilate obstructed airways. Such drugs include long acting beta agonists (LABAs) that are paradoxically linked to excess asthma-related mortality. Here we show that LABAs such as salmeterol and structurally related β2-AR drugs such as formoterol and carvedilol, b...
BACKGROUND Vitamin D deficiency has been declared a public health problem for both adults and children worldwide. Asthma and related allergic diseases are the leading causes of morbidity in children. The objective of this study was to investigate the potential role of Vitamin D deficiency in childhood asthma and other allergic diseases such as allergic rhinitis and wheezing. MATERIALS AND MET...
BACKGROUND The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. OBJECTIVE Def...
Abstract Allergic asthma is a chronic inflammatory disease affecting the lungs which mediated by allergen-specific IgE and type 2 cytokines. cytokine production require Tfh13 cell Th2 polarization, respectively, must first be primed dendritic cells (DC). Recent studies demonstrate that cellular metabolic perturbations critically regulate DC activation subsequent T priming. To characterize mecha...
Objective/purpose Fenretinide [N-4-hydroxyphenyl, 4HPR] is a synthetic retinoid derived from vitamin A with pro-apoptotic and anti-inflammatory properties. Studies have shown that at high concentrations fenretinide is an effective antineoplastic agent, regulating cell growth and differentiation. We have recently demonstrated that fenretinide, at doses 5-10× lower than for cancer treatment, has ...
There is very limited knowledge about the effects of alcohol on airway hyperresponsiveness and inflammation in asthma. Historical accounts of alcohol administration to patients with breathing problems suggest that alcohol may have bronchodilating properties. We hypothesized that alcohol exposure will alter airway hyperresponsiveness (AHR) and pulmonary inflammation in a mouse model of allergic ...
Little is known about the features of asthma and allergy in the elderly. A significant number of elderly patients with asthma have uncontrolled and severe asthma. This review aims to provide an analysis of the literature on the assessment and phenotype of severe allergic asthma in the elderly. Gaps and pitfalls in diagnostic and therapeutic approaches, as well as management of severe allergic a...
The role of female sex hormones in the development and severity of allergic and non-allergic asthma.
Allergic asthma is usually diagnosed by the presence of variable airway obstruction, bronchial hyperresponsiveness, and allergy. However, a significant proportion of adult asthma patients (up to 40%) are non-allergic. Patients with non-allergic asthma often have a later disease onset and greater disease severity, as reflected by more severe airway obstruction and bronchial hyperresponsiveness. ...
Asthma patients show evidence of a procoagulant state in their airways, accompanied by an impaired function of the anticoagulant protein C system. We aimed to study the effect of recombinant human activated protein C (rhAPC) in allergic asthma patients.We conducted a randomised, double-blind, placebo-controlled, proof-of-concept study in house dust mite (HDM) allergic asthma patients. Patients ...
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