Abstract Background Tachycardia-induced cardiomyopathy (TCM) is a reversible and likely underrecognized form of heart failure. Thus, better understanding the TCM-pathophysiology warranted as underlying early mechanisms that mediate progression TCM remain unclear. Purpose This study aimed to identify cellular TCM. Methods results Human induced pluripotent stem cell cardiomyocytes (iPSC-CM) were ...

A 20 year-old male was admitted with a history of recurrent palpitations from 5 years. Baseline ECG revealed premature ventricular contractions (PVCs) delta waves. Stress showed short non-sustained Ventricular tachycardia (VT). Echocardiography moderate dilation the left ventricle mild reduced systolic function and Ejection fraction estimated to be 42%. Right mildly dilated hypokinetic. Both at...

Chemotherapy related cardiac dysfunction (CRCD) is a serious complication of anticancer therapy. CRCD can be classified into two types. Type I CRCD is exemplified by anthracyline- induced cardiac dysfunction and type II CRCD is exemplified by trastuzumab- induced cardiac dysfunction. The mechanism of cardiac toxicity in both types is not well defined. Certain risk factors may play a role in dev...