Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ ...

Background: Type 2 diabetes (T2D) in the elderly is an epidemic that has major impact on global health. Thus this experimental study aimed to compare the response of microRNA-133a (miR-133a) in different tissues and of Runt-related transcription factor 2 (Runx2) in bone marrow tissue following resistance and endurance training in old rats with high-fat diet and streptozotocin (HFD/STZ)-induced ...

background and objective: staphylococcus aureus is an important infection in hemodialysis patients. we studied the prevalence of nasal carriage of methicillin-resistant staphylococcus aureus (mrsa) and its antibiotic resistance pattern in patients receiving hemodialysis as well as in dialysis unit staff. materials and methods: from june to september 2012, we evaluated 74 cases including 61 pati...

The antigenicity of several well established Moloney virus-induced transplantable leukemias was studied. Resistance was developed by pretreatment of isologous mice with x-radiated tumor tissue. In general, the neoplasms grew more rapidly in preirradiated mice (400 r) than in normal mice, and at low inoculum concentrations a higher percentage of tumors was observed in the pre-irradiated animals....

Endoplasmic reticulum (ER) stress is associated with obesity-induced insulin resistance, yet the underlying mechanisms remain to be fully elucidated. Here we show that ER stress-induced insulin receptor (IR) down-regulation may play a critical role in obesity-induced insulin resistance. The expression levels of IR are negatively associated with the ER stress marker C/EBP homologous protein (CHO...

heart produces and secretes a hormone called atrial natriuretic peptide. the aim of this research was to investigate the effect of eight weeks of resistance and sprint training on anp of non-athlete men. 36 non-athlete healthy men were randomly divided into three groups (12 subjects each group): resistance (mean age ± sd: 33.1±2.9 years), sprint (mean age ± sd:  32.1±2.5 years) and control (mea...

new-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. fifty-one non-diabetic traumatized patients...

Cancer cell adhesion confers a transient, de novo drug-resistant phenotype referred to as cell adhesion-mediated drug resistance (CAM-DR). In this report, we extend the CAM-DR phenotype to primary specimens from patients with myeloma, providing further evidence that CAM-DR is a viable clinical form of drug resistance. To examine mechanisms of cellular resistance to melphalan, we compared genoty...