On 9 February 2000 alosetron (marketed as Lotronex by GlaxoSmithKline), a type 3 serotonin (5-HT3) receptor antagonist, was approved by the US Food and Drug Administration (FDA) for the treatment of patients with irritable bowel syndrome, a benign though unpleasant disorder that affects one in five adults in the industrialised world. By November 2000, the FDA had received 49 reports of ischaemi...

introduction: the increasing global consensus built on empirical evidence, expresses that the world, is facing a threat from climate change. as a result, this can affect the agricultural sector through its productivity changes and so influence food security in the world. this can be more intuitive for countries that are dependent on agriculture. agriculture is an important sector in iran that p...

Coastal Healthcare said the listing will “enhance liquidity of our shares, allow us to diversify shareholder base, broaden recognition with investment community and further enhance value.” (Wall Street Journal, 11/29/94); Jon Shirley, Microsoft's president chief operating officer, split “reflects company's desire make stock more accessible a broader base investors.” 8/4/87); Sandoz Ltd. Basle, ...

There is little doubt that the elderly population of the world is growing. The greatest growth in this segment of society happens to be in the industrialized nations and is becoming a serious public policy issue, which will have a dramatic economic impact. Many approaches to solving this problem have been presented from various perspectives. In the current work, we examine the challenges associ...

Critical control systems are often built as a combination of a control core with safety mechanisms allowing to recover from failures. For example a PID controller used with triplicated inputs and voting. Typically these systems would be designed at the model level in a synchronous language like Lustre or Simulink, and their code automatically generated from these models. We present a new analys...

This paper discusses the political relevance of ICT-architecture through a review of recent developments in the Netherlands, involving the bumpy introduction of a national smart card for public transport and the plans for electronic traffic pricing based on actual road usage of individual cars. One of the underlying themes is the centralised or decentralised storage of privacy-sensitive data, w...

The mainstream economic theory generally assumes that the characteristics of the products are obvious for the consumer who can choose between any given product on the basis of prices and preferences. This simplistic presentation of product qualities is discussed by many researchers in socio-economics through the theme of measurement: How are qualities evaluated? What role do physical characteri...