CUTE THROMBOCYTOPENIA is a rare but fairly well-documented complication of infectious mononucleosis.1’8 There is, however, little information on platelets in uncomplicated cases. In most accounts of the disease, platelet levels are either ignored or stated to be normal, and actual counts have been found in only two reports.2’3 Limarzi et al.2 investigated 25 cases and found that platelet levels...

The aim of this study was to analyze the demographic, clinical and laboratory characteristics and prognoses of children diagnosed with infectious mononucleosis (IM). The demographic features, referral complaints, clinical and laboratory findings, follow-up, and prognoses of 44 patients diagnosed with IM between January 2000 and June 2006 at the Infectious Diseases Department of Hacettepe Univer...

During the past fifteen years, and especially during the last seven years, considerable interest has centred round the cases which have been variously described Under the title of " the lymphocytosis of infection," infectious mononucleosis,." " acute benign lymphoblastosis," and " glandular fever," which though not Ve?y common are yet sufficiently frequent to be of 1]nportance, both from the th...

infectious mononucleosis (5) and is one possible etiological agent of Burkitt lymphoma and nasopharyngeal carcinoma (6, 7). When the virus infects a young child, silent seroconversion is the rule. In contrast, primary infection of young adults results in infectious mononucleosis in about one-half of the cases (6). The observations of fatal infectious mononucleosis, agammaglobulinemia, and aplas...

Serological investigations performed on 27 patients with illnesses resembling infectious mononucleosis showed a significant increase in high antibody titres (more than 1:40) to EB virus in 11 of the 12 who developed heterophile antibodies. Two of these patients, however, had a significant increase in antibody titre to cytomegalovirus and rubella virus, respectively. Of 15 patients who failed to...

Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymp...

Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with li...

A modification of the test for EB virus/IgM introduced by Schmitz and Scherer (1972) is described. It is simple and gives reproducible results.EB virus/IgM was demonstrated in all but one case of infectious mononucleosis and in students with minor illness shown to have acquired EB virus/IgG recently. Unlike the EB virus/IgG, the IgM disappears within a few months. Although the Paul-Bunnell-Davi...

At least 90% of the sequences of purified, in vitro labeled, DNA from Epstein-Barr virus (prepared from HR-1, Burkitt's lymphoblastoid cells) are homologous to the DNA of the herpes virus contained in cell lines derived from patients with infectious mononucleosis. The thermal stability of the homologous and heterologous hybrid DNA molecules could not be differentiated, indicating at least 97% m...