The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were geno...

We present a case of infective endocarditis (IE) diagnosed by the increased (99m)Tc-UBI specific uptake in the tricuspid valve region. In conclusion, our case data may indicate a first pass-like distribution with strong avidity of the tracer to infective endocarditis, facilitating image interpretation.

Vertebral osteomyelitis is an uncommon complication of infective endocarditis with the organism Streptococcus viridans being a rare cause of the condition. This case highlights an unusual presentation of Streptococcus viridans associated with infective endocarditis and pyogenic osteomyelitis in a patient following a dental procedure.

Cerebral haemorrhage occurs rarely in infective endocarditis. Here, we present a case of young female with severe intracerebral haemorrhage. Later, she found to be a case of infective endocarditis with mitral valve prolapse and on investigation blood culture grew S. aureus.

Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particul...

introduction: infective endocarditis is well known to produce neurologic complications from septic emboli, which mandates a multidisciplinary approach between neurosurgery and cardiac surgery. however, literature is not clear as to the optimal interval length between neurosurgery and cardiac surgery.presentation of cases: the first case involves a 60-year-old woman with significant past medical...

Objective: To assess the clinical validity of polymerase chain reaction (PCR) based molecular methods in the microbiological diagnosis of culture negative infective endocarditis in a group of surgically treated patients. Design: Retrospective case–control study. Setting: Reference cardiovascular surgical centre. Patients and samples: 15 culture negative patients with infective endocarditis clas...

In 1885 Osler described the clinical course of infective endocarditis (1). Until the introduction of antibiotics the course of the disease was mostly fatal. The introduction of penicillin in 1941 made the disease treatable. However the mortality was considerable, mainly due to heart failure secondary to valve destruction.(2). In 1960 Kay was the first one to report surgical treatment for a valv...

INTRODUCTION Mitral annular calcification is a common finding in elderly patients; it is considered a benign cardiac abnormality but it can be a predisposing factor for infective endocarditis. Although described in numerous necropsy studies, endocarditis on mitral annular calcification has rarely been reported during life, and the frequency of sepsis can be underestimated because of difficult d...

INTRODUCTION Right-sided infective endocarditis is rare. It accounts about 5 to 10% of all infective endocarditis cases and is prevalent in patients with congenital heart disease, intravascular devices and drug addiction. Our study aimed to describe the epidemiological, clinical and echocardiographic characteristics of right-sided endocarditis and evaluate the prognosis after treatment. METHO...