Obesity has reached epidemic proportions in most of the western world. With obesity comes a variety of adverse health effects such as insulin resistance, dyslipidemia, hypertension, glucose intolerance, and hepatic steatosis. It has become clear that a state of low grade chronic inflammation, typically associated with obesity, and characterized by macrophage infiltration of adipose tissue (AT) ...

Ceramic matrix composites (CMCs) is one of the most promising candidates for high temperature structural material, in which SiC matrix exhibits an excellent oxidation resistance because of the formation of a protective layer of silica which limits further oxidation [1]. CMCs with continuous fibers exhibit attractive properties such as low densities, high elastic moduli, and high strengths at el...

T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors. As a member of the HER family of tyrosine kinase receptors, its over-activity confers unfavorable clinical outcome. Targeted therapies directed at this receptor have achieved respons...

Increased adipose tissue macrophages contribute to obesity-induced metabolic syndrome. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with potent anti-inflammatory and proangiogenic activities in macrophages. However, the role of macrophage HO-1 on obesity-induced adipose inflammation and metabolic syndrome remains unclear. Here we show that high-fat diet (HFD) feeding in C57BL/6J mice in...

Water-repellent soils have a potential as alternative construction materials that will improve conventional geotechnical structures. In this study, the potential of chemically treated water-repellent kaolin clay as a landfill cover material is explored by examining its characteristics including hydraulic and mechanical properties. In order to provide water repellency to the kaolin clay, the sur...

Antiangiogenic strategies can be effective for cancer therapy, but like all therapies resistance poses a major clinical challenge. Hypoxia and nutrient starvation select for aggressive qualities that may render tumors resistant to antiangiogenic attack. Here, we show that hypoxia and nutrient starvation cooperate to drive tumor aggressiveness through epigenetic regulation of the histone demethy...

In order to further enhance the Ni/Ce 0.8Gd0.2O2-δ (Ni/GDC20) cermet anodic performance for low temperature solid oxide fuel cell (LT-SOFC), a study was conducted on the nanostructuring of NiO/GDC composite by only once wet-infiltration of rhodium chloride precursor. By using electrochemical impedance spectroscopy (EIS) analysis, the effect of only one drop of Rh-infiltrating solution on ...

abstract this study addresses two dimensional infiltration from irrigated furrows. the basic approach is to develop a two-dimensional infiltration as a combination of the corresponding one-dimensional vertical and an edge effect. the edge effect is the difference between the cumulative infiltration per unit of adjusted wetting perimeter and the corresponding one-dimensional infiltration. this a...