Cardiovascular diseases are a class of heart or blood vessels diseases, which are now considered to be the leading cause of death globally. A number of recent studies have reported key roles for inflammation in the progression of diseased vessels and systematic heart failure. In particular, endoplasmic reticulum (ER) stress, which is mechanistically implicated in inflammation and autophagy, has...

Inflammation is one of main mechanisms of autoimmune disorders and a common feature of most diseases. Appropriate suppression of inflammation is a key resolution to treat the diseases. Sirtuin1 (Sirt1) has been shown to play a role in regulation of inflammation. Resveratrol, a potent Sirt1 activator, has anti-inflammation property. However, the detailed mechanism is not fully understood. In thi...

Inflammation of the upper respiratory tract in patients with allergic rhinitis (AR) may contribute to lower airways’ inflammation. T-helper 17 (Th17) cells and related cytokines are also involved immunological mechanism AR along classical Th2 cells. It is hypothesized that upon pressure, inflammatory response lungs lead Th17-induced neutrophilic However, findings for interleukin-17 (IL-17) bidi...

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age-associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection...

Uncontrolled inflammation is a feature of autoimmune diseases and autoinflammatory syndromes and may promote tumorigenesis. Thus, identifying molecules that regulate the signaling pathways triggering, mediating, and suppressing inflammation could be helpful in developing new therapeutic approaches for these debilitating diseases. In this review, we present new information on three molecules wit...

Glomerular diseases are the leading cause of ESKD worldwide. IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), Alport syndrome (AS), and diabetic kidney disease (DKD) important glomerular characterized by proteinuria, a predictor progression ESKD. Endothelin A (ETA) receptor activation drives inflammation, fibrosis. Therefore, atrasentan, potent selective ETA antagonist, has po...

Background: Pyroptosis is defined as programmed necrosis executed by gasdermin D or E (GSDMD GSDME), which punches cellular membrane. Morphologically, pyroptosis characterized cell swelling and membrane rupture, leading to the release of contents that triggers intense inflammatory response. More more studies have found may be involved in pathogenesis viral infection, a determinant for inflammat...

Inflammation is a comprehensive array of physiological response to a foreign organism, including human pathogens, dust particles, and viruses. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. Recent investigations have clarified that inflammation is a major factor for the progression of various chronic dise...

Inflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites. Innate immunity, mediated by mononuclear phagocytes, including monocytes and macrophages, is a first line of defense against infectious diseases and plays a key role triggering the delayed adaptive response that ensures an efficient defens...