Persistent endoplasmic reticulum stress promotes aberrant inflammation and induces cell death, is implicated in the pathogenesis of pneumonia. Vanillic acid exerts pharmacological activities, such as anti-inflammatory, antimicrobial, antioxidant effects. However, role vanillic pneumonia has not been elucidated yet. Human lung fibroblasts (WI-38 MRC-5) were incubated with different concentration...

BACKGROUND High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic components of the metabolic syndrome. METHODS AND RESULTS We performed a factor ...

Ketamine cystitis (KC) is a chronic bladder inflammation leading to urinary urgency, frequency, and pain. The pathogenesis of KC complicated involves multiple tissue injuries in the bladder. Recent studies indicated that urothelium disruption, lamina propria fibrosis inflammation, microvascular injury, neuropathological alterations, smooth muscle (BSM) abnormalities all contribute KC. has been ...

t lymphocytes that are involved in cellular mediated immunity include two types known as tcd8+ (cytotoxic t lymphocytes) and tcd4+ (helper t lymphocytes). tcd4+ has four main subtypes, including th1, th2, th17, and treg lymphocytes.th17 lymphocytes play a role in defense against microbes that th1 and th2 lymphocytes have not the ability to respond to them. the most important cytokines, which ar...

the novel bicyclo thieno 1, 2, 3-triazines (btt) namely btt-1, btt-2, btt-3 and btt-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (cfa) induced arthritis model was used for anti...