Abstract Background The pathogenesis of type 2 diabetes mellitus (T2DM) originates from multiple tissue defects. Environmental pollutants such like endocrine-disrupting chemicals (EDCs) have lately gotten special attention in triggering the metabolic abnormalities relation to insulin resistance and T2DM. Bisphenol-A (BPA), which is one EDCs simulates natural endogenous estrogens, has been impli...

Abstract Problem Obesity and preeclampsia both involve a pathological inflammatory response, which may be how obesity increases risk. Previous studies have failed to assess robust measurements of markers across gestation, specifically in overweight/ obese women the context preeclampsia. Method study We measured 20 plasma via multiplex assay (ThermoFisher Inflammation plex Human ProcartaPlex Pan...

Background: In acute lymphoblastic leukemia (ALL) the bone marrow loses its ability in the differentiation and maturation of blood cells at different stages. Zinc and copper are important co-factors for several enzymes and play an important role in maintenance of DNA integrity. Changes in serum levels of zinc and copper have been found in lymphoproliferative disorders. In the present study, the...

Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS). EAE and MS are characterized by CNS inflammation, demyelination and neurodegeneration. The inflammatory response occurring within the CNS leads to glial activation, dysfunction and death, as well as axonal damage and neurological deficit. Although the pathogenic mechanisms involved in EAE/MS are not ...

Abidi and colleagues recently reported that eosinopenia constitutes a good diagnostic marker in distinguishing between noninfection and infection, but is a moderate marker in discriminating between systemic inflammatory response syndrome and infection in newly admitted critically ill patients [1]. They propose that eosinopenia may become a helpful clinical tool in intensive care unit (ICU) prac...

Introduction Kawasaki disease (KD) is an acute self-limited vasculitis, in which 1/3 of patients develop coronary artery lesions (CAL) if untreated. Although studies have explored potential biomarkers to predict patients with KD who are at risk of CAL, no useful single marker exists. The blood neutrophil to lymphocyte ratio (NLR) is identified as a potentially useful marker of clinical outcome ...

With these limitations, researchers and clinicians look at the inflammatory cascade for a potential objective serum marker of infection. By definition a serum marker should be absent if the patient is not infected, appear concomitantly and ideally precede the clinical manifestations of infection, disappear with successful therapy or remain elevated if infection is refractory to treatment. Seria...