20 Context-sensitive half-times (CSHTs) of fentanyl in dogs were determined using 21 pharmacokinetic models reported by Murphy et al. and Sano et al., and compared with a 22 human model. The CSHT was defined as the time required for a 50% decrease in drug 23 concentration in the central compartment after the termination of infusion. Although 24 CSHTs increased gradually as the infusion time inc...

Hematopoietic stem cell infusion is an important procedure in Hematopoietic Stem Cell Transplantation (HSCT). This study identifies transfusion and other adverse reactions that can occur during infusion and the nursing care related to the procedure. This epidemiologic study used transplantations performed between 2006 and 2008. A total of 166 transplantations were performed: 114 were autologous...

The purpose of these experiments was to determine if arginine vasopressin (AVP) contributes to the blood pressure elevation induced by salt excess in renal insufficiency. Conscious rats were studied 6 days after surgical removal of 85% renal mass, which resulted hi renal Insufficiency as evidenced by an elevation in BUN and creatlnine. Four groups of subtotally nephrectomized animals were studi...

Monte Carlo simulation was used to assess the type I error rate and rank order of power for six different metrics using linear mixed-effect models, including two variables recommended by the European Agency for the Evaluation of Medicinal Products (EMEA) in the analysis of QTc interval data. The metrics analyzed were maximal change in QTc interval from baseline, maximal QTc interval, area under...

Methods A cohort study of 57 PID patients was reviewed 3 months post-transition to the 20% Subcutaneous Immunoglobulin (HizentraTM), in order to evaluate clinical outcomes and adverse events related to a dose-equivalent switch from 10% liquid solution intravenous (Privigen and Gamunex) or 16% subcutaneous replacement therapy (Vivaglobin) to weekly infusion of HizentraTM, Descriptive analyses we...

results there was no difference found between the two groups with regard to; gender, basic variables, ejection fraction (ef), cbp time and aortic cross-clamp time. the preoperative levels of il-6 and tnf-α were not different; however, their postoperative levels were significantly higher in the placebo group (p value = 0.01 for il-6 and 0.005 for tnf-α). conclusions this study showed that mgso4 ...

Abstract Background Partial hepatectomy is an effective treatment for benign and malignant liver diseases . However, intraoperative bleeding one of the major factors affecting outcome hepatectomy. Currently, most commonly used method hepatic blood flow occlusion in clinical practice Pringle method, but this has a great impact on function can cause ischemia-reperfusion injury. .Studies have show...

background: oxytocin infusion is used for induction or augmentation of labor to prevent prolonged labor. a cheap and nonaggressive alternative which is effectively used for contraction stress test is nipple stimulation. however research regarding its efficacy and safety is still limited. this study aims to compare the effectiveness of nipple stimulation and oxytocin infusion on the duration of ...

Chicken eggs are animal foods that consumed by many people because they cheaper and easier to obtain than other foods. Bay leaf is known the public as one of most popular kitchen spices not only its health benefits, but also attractive organoleptic quality (aroma). Eggs soaked in bay infusion expected produce qualities without affecting their chemical (fat content).
 The research design us...