Protein stability is based on a delicate balance between energetic and entropic factors. Intrinsically disordered proteins (IDPs) interacting with a folded partner protein in the act of binding can order the IDP to form the correct functional interface by decrease in the overall free energy. In this work, we evaluate the part of the entropic cost of ordering an IDP arising from their dihedral s...

Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that promotes duplex formation of diverse IDP partners. N...

BACKGROUND Intrinsically disordered proteins (IDPs) lack a stable tertiary structure in isolation. Remarkably, however, a substantial portion of IDPs undergo disorder-to-order transitions upon binding to their cognate partners. Structural flexibility and binding plasticity enable IDPs to interact with a broad range of partners. However, the broader network properties that could provide addition...

Denicolò and Polo (2018) show that the result of Federico et al. (2017), i.e., horizontal mergers reduce R&D investments merged firms compared to non-cooperation, holds provided probability failure in is log-convex investments. We provide a different reason for innovation raising merger. if invest process innovation, merger may increase even as considered (2017). also expected consumer surplus ...

Isolated duodenal perforation (IDP) in pediatric trauma is rarely reported. Since most of the children with blunt trauma are managed expectantly, timely diagnosis is imperative to avoid morbidity and mortality. We report a case of IDP and emphasize on certain specific clinical features indicating possibility of duodenal injury. We also stress upon the role of early contrast-enhanced computerize...

This paper develops a mathematical model of innovation in technology with two main characteristics. First, it discusses the endogenously made decision on not only how much to innovate, but also, how much to imitate. Second, it demonstrates that the decision to innovate or imitate are not mutually exclusive and a firm can innovate and imitate simultaneously. A mathematical model is presented, an...

The continuous innovation process of the Information and Communication Technology (ICT) sector shape the way businesses redefine their business models. Though, current drivers of innovation processes focus solely on a technical dimension, while disregarding social and environmental drivers. However, examples like Nokia, Yahoo or Hewlett-Packard show that even though a profitable business model ...

This Learn About discusses the complex security threats businesses are facing and how the technology behind intrusion detection and prevention (IDP) can prevent attacks on business networks. Juniper Networks has offered IDP for years, and today it is implemented on thousands of business networks by the Juniper Networks SRX Series Services Gateways and Juniper Networks JSA Series Secure Analytic...