Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valuable molecular tags for cancer gene discovery. Here we show that insertional mutagenesis can also identify genes that promote the immortalization of hematopoietic cells, which normally have only limited self-renewal. Transduction of mouse bone marrow cells with replication-incompetent murin...

this case report presents a coincidence of trisomy 18 and balanced robertsonian translocation (13;14). aneuploidy was suspected based on anomalies detected in ultrasound scan and confirmed with karyotype. in a 31 years-old healthy woman with a history of one miscarriage, second trimester ultrasound scan reported iugr (<3rd percentile) with normal amniotic fluid, bilateral choroid plexus cysts, ...

jak2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. a single acquired point mutation – v617f – in jak2 occurs in the great majority of patients with polycythemia vera (pv) and approximately half of the patients with idiopathic myelofibrosis (imf) or essential thrombocythemia (et). in contrast, the jak2-v617f mutation is...

brassica chinensis l. is a popular vegetable, especially in asian dishes. for plant growing withinorganic fertilizer, cadmium (cd) has been one of the highest metal and health-risk factors included. thisresearch aimed to assess the bioaccumulation of cd by the plant and its genetic changes. the plant was grownin the soil supplemented by cd at 0, 15, 30, 60 and 120 mg/kg. the accumulations in th...

This report described a 46-year man with the characteristic Computerized Tomography (CT) scan findings of Corona Virus Disease Infection 19 (COVID-19) who presented to hospital right ankle weakness three weeks after pneumonitis. He had been initially hospitalized, complaining fever, myalgia, cough, and dyspnea. Electromyogram (EMG) revealed obvious evidence increased insertional activity (IA) s...

Adenoviruses (Ad) have a long history as DNA-transfer vehicles in various medical applications including vivo gene therapy [1]. In this context, the favorable safety profile of Ad has been considered major benefit, since lack integration into host cell genome eliminates potential risks associated with insertional mutagenesis. This is combined comparatively high packaging capacity for foreign DN...

BACKGROUND AND OBJECTIVE insertional Achilles tendinopathy is a common condition among athletes and joggers. One fifth of the injuries involves the insertion of the tendon. The etiology is either due to mechanical overuse related to sports activity, or a systemic inflammatory disease. The clinical appearance includes pain and movement restriction. The primary treatment is conservative. The surg...

Achilles tendinopathy is a very common pathology, especially in the athletic population. Its etiology is multifactorial and the underlying pathophysiology is still not fully understood. For non-insertional tendinopathy is increasingly recognized the influence of paratendinopathy in the genesis of patients symptoms, so various surgical treatments have been accordingly developed; they are indicat...

BACKGROUND AND PURPOSE While the etiology and clinical features of "EMG disease" - which is characterized by diffusely increased insertional activity on needle electromyography (EMG) in the absence of neuromuscular disease - are not well known, some authorities believe it may be a form of myotonia congenita (MC). The aims of this study were to determine the clinical features of EMG disease and ...

OBJECTIVE This study was performed to evaluate the insertional properties of two cochlear implant electrodes recently developed by Advanced Bionics Corporation. STUDY DESIGN Anatomic study using human cadaveric temporal bones. METHODS The electrode prototypes we tested are the Thin Lateral and Helix II arrays, which incorporate features designed to minimize insertional trauma. A total of ei...