Sirtuins are evolutionary conserved NAD+ dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins represent a promising new class of III NAD dependent histone deacetylases that regulate a number of physiological processes, originally identified in yeast. Sirtuins regulate various normal and abnormal ce...

Deep insight on cell cycle, checkpoints and cáncer.

ever-changing manner. The effect of a signal transmitted synaptically from one neuron to another can vary enormously, depending on the recent history of activity at either or both sides of the synapse, and such variations can last from milliseconds to months. Activity-dependent changes in synaptic transmission arise from a large number of mechanisms known collectively as synaptic plasticity. Sy...

The itch sensation results from the excitation of primary sensory nerve endings in the skin, but the underlying molecular mechanisms are not completely understood. Liu et al. (2009) now report that some members of the Mrgpr class of G protein-coupled receptors mediate the itch caused by the antimalarial drug chloroquine.

Spinophilin is a scaffolding protein with modular domains that govern its interaction with a large number of cellular proteins. The Spinophilin gene locus is localized at chromosome 17q21, a chromosomal region frequently affected by genomic instability in different human tumours. The scaffolding protein interacts with the tumour-suppressor ARF which has suggested a role for Spinophilin in cell ...

1 0. 10 83 /j cb. 17 23 it i3 j cb 17 23 it i3 Nicole [email protected] ewt ins ight into regenerat ion L imb regeneration, as seen in amphibians, might not be as far from humanly possible as once thought. On page 433 , Morrison et al. show that the regeneration of newt limbs hinges on the activation of muscle satellite cells—t...

During cell division the genome is duplicated and segregated along with organelles into the daughter cells with high fidelity. The physical separation of the two daughter cells topologically resembles virus budding and multivesicular endosome (MVE) formation in the sense that they all involve outward budding from cytosol. According to the crucial role of the Endosomal Sorting Complex Required f...

An evaluation of patients’ insight into their mental illness has long been included in the standard mental state examination. The last 10 years have shown a resurgence of interest in insight, with better definitions and operationalizations of the concept. Insight into psychosis is seen as the ability of patient for self observation and knowledge about his illness. This has received scant attent...

BACKGROUND In March 1995, The Chief Medical Examiner, Province of Manitoba, ordered an inquest into the deaths of 12 children who died in 1994 while undergoing or shortly after having undergone cardiac surgery at Health Sciences Centre in Winnipeg, Manitoba, Canada. The inquest spanned over five years, and resulted in almost 50,000 pages of transcript, including the testimony of more than 80 wi...