Many perceptual and physiological studies of sound localization have explored the precedence effect (PE), whereby a pair of brief sounds coming from different directions and arriving at the ears close together in time is perceived as coming from a location near that of the first-arriving sound. Here, we used a computational model of low-frequency inferior colliculus (IC) neurons to account for ...

BACKGROUND Internal tandem duplication of FMS-like tyrosine kinase (FLT3-ITD) is well known to be involved in acute myeloid leukemia (AML) progression, but FLT3-ITD-negative AML cases account for 70% to 80% of AML, and the mechanisms underlying their pathology remain unclear. This study identifies protein tyrosine phophatase PRL-3 as a key mediator of FLT3-ITD-negative AML. METHODS A total of...

Binaural hearing, the ability to detect small differences in the timing and level of sounds at the two ears, underpins the ability to localize sound sources along the horizontal plane, and is important for decoding complex spatial listening environments into separate objects - a critical factor in 'cocktail-party listening'. For human listeners, the most important spatial cue is the interaural ...

Abstract Integration is often considered the core challenge and defining characteristic of inter- trans-disciplinary (ITD) research. Given its importance, it surprising that current system higher education does not provide permanent positions for integration experts; i.e., experts who lead, administer, manage, monitor, assess, accompany, and/or advise others on within ITD projects or programs. ...

Distributive lattices with operators (DLO) are a natural generalization of the notion of Boolean algebras with operators. An operator in a bounded distributive lattice A is a function f : An → A which preserves ∧ (or ∨) in each coordinate. In the last few years these classes of algebras have been actively investigated since they appear as algebraic counterpart of many logics. Some important con...

Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of si...

Current clinical practice in programming a cochlear implant (CI) for individuals with single-sided deafness (SSD) is to maximize the transmission of speech information via the implant, with the implicit assumption that this will also result in improved spatial-hearing abilities. However, binaural sensitivity is reduced by interaural place-of-stimulation mismatch, a likely occurrence with a stan...

A function of the auditory system is to accurately determine the location of a sound source. The main cues for sound location are interaural time (ITD) and level (ILD) differences. Humans use both ITD and ILD to determine the azimuth. Thus far, the conception of sound localization in barn owls was that their facial ruff and asymmetrical ears generate a two-dimensional grid of ITD for azimuth an...

While handling deformable linear objects (DLOs), such as hoses, wires or leaf springs, with an industrial robot at high speed, unintended and undesired oscillations that delay further operations may occur. This paper analyzes oscillations based on a simple model with one degree of freedom (DOF) and presents a method for active open-loop damping. Different ways to interpret an oscillating DLO as...