caused by human papilloma virus(HPV) coming from the papova family. They are a common dermatologic complaint, with an estimated incidence of 10% in children and young adults1. Commonly warts occur at the periungual areas and pose a problem in the management2 . Interferons have been used for the treatment of viral disease, cutaneous tumors, HIV-associated Kaposi’s sarcoma and other inflammatory ...

PURPOSE Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV combination treatment using HCV cell culture. METHODS The antiviral efficacy of IFN-α, RBV alone...

Introduction . Interferon-containing drugs are frequently used, but their effect on the innate immune cells response and adaptive immunity parameters is not well known. Aim To investigate of interferon-alpha-containing production neutrophil extracellular traps, population subpopulation composition peripheral blood lymphocytes in cell culture conditions. Materials methods We used from 12 healthy...

BACKGROUND Isopropyl-β-D-1-thiolgalactopyranoside (IPTG)-inducible expression of recombinant proteins in E. coli is commonly used and effective. Nevertheless, unintended induction was encountered as a problem when using these bacterial expression systems, generating cultures that give reduced or variable protein yields. Auto-induction allows for production of much higher target protein yield an...