نتایج جستجو برای: interlaminar peel and shear stress
تعداد نتایج: 16915917 فیلتر نتایج به سال:
Hemodynamic shear stress regulates endothelial cell biochemical processes that govern cytoskeletal contractility, focal adhesion dynamics, and extracellular matrix (ECM) assembly. Since shear stress causes rapid strain focusing at discrete locations in the cytoskeleton, we hypothesized that shear stress coordinately alters structural dynamics in the cytoskeleton, focal adhesion sites, and ECM o...
The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined variations in shear stress in a straight vessel segment of a mouse. To this end, a cylinder with a tapered lumen was placed around the carotid artery, inducing a high shear stress field. Concomitantly, regions of low shear stress and oscillatory...
The free edges of layered structures require special attention in design processes. Due to the discontinuous material properties, singular stress concentrations occur where layer interfaces meet edge. These bi-material points have be closely examined as possible starting for delamination In present study, we propose an efficient approximate closed-form method analyze interlaminar shear stresses...
Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations. Endothelial cells adapt to shear stress by remodeling their cytoskeletal components and subsequently by changing their shape and orientation. We demonstrate that β1 integrin activation is critically controlled during the mechanoresponse of endothe...
BACKGROUND AND PURPOSE Little attention has been focused on the role of fluid-induced wall shear stress in fully developed cerebral aneurysms. The purpose of this study is to evaluate the alternation and distribution of wall shear stress over 1 cardiac cycle in patients' aneurysms. METHODS A middle cerebral artery aneurysm and a basilar tip aneurysm with localized outpouching (blebs) in their...
context lumbar central spinal stenosis is common and often results in chronic persistent pain and disability, which can lead to multiple interventions. after the failure of conservative treatment, either surgical or nonsurgical modalities such as epidural injections are contemplated in the management of lumbar spinal stenosis. evidence acquisition recent randomized trials, systematic reviews an...
Shear stress due to mechanical loading-induced flow of interstitial fluid through the lacuno-canalicular network is a likely signal for bone cell adaptive responses. Moreover, the rate (determined by frequency and magnitude) of mechanical loading determines the amount of bone formation. Whether the bone cells' response to fluid shear stress is rate dependent is unknown. Here we investigated whe...
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