Ischemia-reperfusion and hyperoxia-induced pulmonary injury are associated with the presence of activated neutrophils (PMN) and cellular injury. Although the signals orchestrating the directed migration of these PMN during the pathogenesis of these disease states remain to be fully elucidated, it appears they may be dependent upon the production of certain neutrophil activating/chemotactic fact...

A potent leukocyte chemotactic and activating cytokine, interleukin-8 (IL-8), is produced by numerous types of cells in response to inflammatory stimuli. Accumulating evidence indicate that the transcription of IL-8 gene requires the activation of either the combination of NF-kappa B and AP-1 or that of NF-kappa B and NF-IL6, depending on the type of cells. Alternatively, the activation of NF-k...

A sthma is characterized by the presence of airway inflammation that results in bronchial hyperresponsiveness and symptoms of airway obstruction. Persistent and severe asthma may have an eosinophilic or noneosinophilic infiltration of the airways, the latter characterized by a profusion of neutrophils.1 More recent findings implicate that neutrophils may play a role in the irreversible airflow ...

The adult respiratory distress syndrome (ARDS), a process of diffuse inflammation and increased permeability of pulmonary microvasculature, carries a high morbidity and mortality (40-90%) (1). Neutrophils have received a great deal of attention as the primary effector cells of this disease process. There is a marked increase in the numberofneutrophils in the alveolar spaces. High concentrations...

We have previously shown that interleukin-8 (IL-8), a cytokine with neutrophil chemotactic/activating and T cell chemotactic activity, is produced by human endometrial stromal and glandular cells in culture. The present study investigated the temporal and spatial expression of IL-8 messenger ribonucleic acid (mRNA) and protein in the human endometrium. Endometrial tissue (n = 52) was obtained f...

CONTEXT Obstructive pancreatitis is a specific form of pancreatitis, which is caused by the obstruction of the main pancreatic duct due to tumors or some other causes. Interleukin-8 is induced in acute pancreatitis, but its expression in obstructive pancreatitis has not been clarified. OBJECTIVE We attempted to provide some insight into the significance of interleukin -8 in the pathogenesis o...

Interleukin 8 is a neutrophil chemotactic and stimulating cytokine induced by various inflammatory stimuli, including tumour necrosis factor, interleukin 1, and endotoxin. The ability of HT 29/19A enterocytes to synthesise interleukin 8 was studied. The results show that interleukin 1 is an important stimulus for interleukin 8 synthesis and secretion by HT 29/19A cells, being more potent than t...