In contrast to an expected Ostwald-like ripening of amyloid assemblies, the nucleating core of the Dutch mutant of the Aβ peptide of Alzheimer's disease assembles through a series of conformational transitions. Structural characterization of the intermediate assemblies by isotope-edited IR and solid-state NMR reveals unexpected strand orientation intermediates and suggests new nucleation mechan...

Baird, W. M.,Dipple, A.,Grover,P. L.,Sims,P. &Brookes,P. (1973) Cancer Res. 33,2386-2392 Booth, J. & Sims, P. (1974~) Biochem. Pharmacol. 23,2547-2555 Booth, J. & Sims, P. (1974b) FEBS Lett. 47,30-33 Booth, J., Keysell, G. R. & Sims, P. (1973) Biochem. Pharmacol. 22,1781-1791 Booth, J., Keysell, G. R., Pal, K. & Sims, P. (1974) FEBS Lett. 43,341-344 Boyland, E. (1950) Biochem. SOC. Symp. 5,4044...

Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.

Oxidative N-heterocyclic carbene (NHC) catalysis offers the chance to perform oxidative and oxygenative transformations which give rise various NHC-bound intermediates, paving way non-umpolung processes through activation of carbon atoms heteroatoms. The aim this review is discuss developments literature in field NHC-catalysis since 2014, with particular focus pivotal intermediates their mechan...

the catalytic oxidation of toluene over copper oxide supported on natural diatomite was investigated. the catalyst was prepared by the wet impregnation method and characterized by using the brunauer emmett teller (bet), field emission scanning electron microscopy (fesem), x-ray diffraction (xrd), x-ray fluorescence (xrf) and temperature-programmed reduction (tpr) analysis. the highest catalytic ...

The reaction pathways of transient radical species are difficult to control, like the soap bubbles in wind depicted cover image. Yet, these short-lived intermediates, when one encounters another, readily assemble into a united structure, as two fuse bigger single bubble. enol silyl ether-derived cations with highly acidic allylic proton facilitates single-electron reduction cyanopyridines via p...

There is accumulating evidence that proteins can be retained in the endoplasmic reticulum by a mechanism that is believed to monitor the oxidation status of one or more cysteines in their sequences. For example, a single cysteine residue critical for retention of secretory IgM assembly intermediates has been mapped to the C-terminal cysteine, Cys575, of the secretory mu chain. Little is known c...

Protein folding intermediates that are sometimes populated at equilibrium under mild denaturing conditions have attracted much attention as plausible models for the kinetic intermediates transiently populated in the refolding kinetic pathways. Hen egg-white lysozyme is often considered as a typical example of close adherence to the equilibrium, two-state unfolding mechanism. However, recent sma...

A major problem in the study of fatty acid metabolism at the subcellular level has been the demonstration of the individual steps of both oxidation and synthesis (1, 2). Oxidation of long and short chain fatty acids by intact mitochondria is considered to proceed directly to acetate, without the accumulation of intermediates (3). Synthesis of fatty acids from acetyl coenzyme A and malonyl-CoA b...