Purpose: In this study; we aimed to compare tumor volume with other prognostic determinants by making stereologic estimation. Material and Methods: In the mastectomy materials of 44 patients; tumor volume was calculated with the Cavaliery principle and compared with the classically known other pathologic variables. Results: There is a statistically significant correlation between histologic gra...

OBJECTIVES/HYPOTHESIS The role of tumor volume in T4a laryngeal cancer remains unclear among different treatment modalities. Using tumor volumetry, we investigated the impact of primary tumor volume on this subset of patients. STUDY DESIGN Retrospective cohort study of 62 T4a laryngeal cancer patients. METHODS From October 2002 to September 2010, 48 patients were treated with definitive che...

Objective(s): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the...

Background and Purpose—Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear. Methods—We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultraso...

The high throughput preparation of emulsions with high internal volume fractions is important for many different applications, e.g., drug delivery. However, most emulsification techniques reach only low internal volume fractions and need stable flow rates that are often difficult to control. Here, we present a centrifugal high throughput step emulsification disk for the fast and easy production...