introduction: drugs of abuse such as nicotine and morphine used systemically by addicts produce their effects via the mesolimbic dopaminergic pathway. furthermore, evidence indicates that some behavioral effects of nicotine and morphine are mediated by nitric oxide (no). based on these observations, the aim of the present study was to investigate the effects of intra-nucleus accumbens (nac) inj...

Introduction: The nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. The neurostreoid, 17β-estradiol found in the PGi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with NMDA receptors. In this study, the role of NMDA receptors in the 17β-estradiol-induced pain modulation was investig...

we report a case of nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. this case is unique because she developed compartment syndrome in her left calf far from her injection site. her toe’s tips gangrened in the course of her ailment. we hypothesized that the compartment syndrome might be produced by a probable intra-arteria...

background:chronic synovitis is one of the most important complications in haemophilic patients. rifampin is anantibiotic which its intra-articular injecion leads to destruction of the synovial membrane of haemophilic patientsmedically.materials and methods: between september 2003 and november 2005, we administered intra-articular rifampinin ١۶ haemophilic joints of ٨ haemophilic patients.resul...

Arthritis is a common disease affecting the temporomandibular joint. The inflammation causes local pain and decreased function of the masticatory system. Temporomandibular joint arthritis can result from mechanical overloading, general autoimmune disease or individual susceptibility. The aim of this study was to investigate objective and subjective treatment results after intra-articular inject...

UNLABELLED Internal radiation therapy using intrahepatic arterial injection of 90Y-labeled glass microspheres (90Y-microspheres) has proven to be a promising therapeutic modality for inoperative liver tumor. Recently, direct intratumoral injection of 90Y-microspheres has been performed with even more encouraging results. The purpose of this study was to compare the treatment efficacy of these 2...

background: assisted reproductive technologies (art) are known as a treatment for infertility in which oocyte undergoes manipulation outside body. the aim of this study was to study the evaluation of birth defects in infants conceived through assisted reproductive technologies (art) and compare them with naturally-conceived infants. materials and methods: in this retrospective study, four hundr...

Recent studies showed that oxytocin plays an important role in nociceptive modulation in the central nervous system. The present study was undertaken to investigate the role of oxytocin in antinociception in the nucleus raphe magnus (NRM) of rats and the possible interaction between oxytocin and the opioid systems. Intra-NRM injection of oxytocin induced dose-dependent increases in hindpaw with...

BACKGROUND Intra-articular injection of hyaluronic acid (HA) is a well-documented treatment for knee osteoarthritis (OA). One of the multifactorial mechanisms is that exogenous HA can stimulate endogenous HA production. HA can regulate the growth and function of chondrocytes by binding to CD44 receptors on the chondrocytes. Synovitis is often found in patients with rheumatoid arthritis (RA) and...