PURPOSE To determine the types of cells in the visual system of the mouse and rat that can express a transgene delivered by an attenuated replication competent Herpes simplex virus-1 (HSV-1) vector. METHODS C57/BL6 x BALB/C mice and Albino rats were treated with 1 x 10(7) pfu of the HSV-1 ribonucleotide reductase mutant (hrR3) expressing the Escherichia coli lacZ gene. The hrR3 virus was deli...

PURPOSE To evaluate the usefulness of intracameral lidocaine in cataract surgery under topical anesthesia and especially if the patient wanted intravenous sedation preoperatively. METHODS In this prospective study 96 patients were randomly assigned to receive 0.5 cc of balanced salt solution (Group 1) or 1% unpreserved lidocaine (Group 2). Patients who wanted sedation received intravenous mid...

PURPOSE To evaluate the efficacy of topical anesthesia with oxybuprocaïne 0.4% without intracameral lidocaïne as an alternative to peribulbar or retrobulbar anesthesia in cataract surgery. METHODS Fifty-eight patients (eighty-two eyes) were included in this study. All patients received topical anesthesia with oxybuprocaïne 0.4%. No intracameral lidocaïne was used at the start of the intervent...

Progressive degeneration of neuroretinal tissue with maintained elevated intraocular pressure (IOP) to simulate chronic glaucoma was produced by intracameral injections poly (lactic-co-glycolic) acid (PLGA) microspheres (Ms) in rat eyes. The right eye 39 rats received different sizes PLGA-Ms (2 µL suspension; 10% w/v): 14 38–20 µm Ms (Ms38/20 model) and 25 20–10 particles (Ms20/10 model). This ...

BACKGROUND Endophthalmitis is one of the most important complications after cataract surgery and in case event can cause many symptoms, such as severe decrease in eyesight and/or even the loss of vision. Employing methods to reduce this problem is very important. The aim of this study was to evaluate the effect of intracameral cefuroxime after cataract surgery on corneal endothelial cell counts...

Background: Mycotic keratitis is a potential sight-threatening infection and leading cause of ocular morbidity worldwide. It inherently difficult to treat due the delayed diagnosis fungistatic nature available topical medications. Aims Objectives: The aim compare safety efficacy intrastromal voriconazole alone in combination with intracameral recalcitrant fungal cases. Materials Methods: A pros...

purpose : round-the-clock on-demand availability and corneal cloudiness are the two major problems with animal eyes for surgical practice. the purpose of this investigation is to assess the usability of long-term deep freezing for the preservation of enucleated sheep eyes and the adjunctive role of intracameral cryoprotective agent on corneal clarity. methods : thirty-two enucleated fresh sheep...

purpose : to examine the safety and efficacy of simultaneous ahmed glaucoma valve (agv) implantation with intravitreal and intracameral injection of bevacizumab (ivb and icb) in patients with refractory acute neovascular glaucoma (nvg) with very high intraocular pressure (iop) and active neovascularization of the iris (nvi) and/or the angle (nva) methods : in a prospective interventional study,...