Antiphospholipid antibodies have an established association with pregnancy complications such as recurrent miscarriage, growth retardation, placental abruption and stillbirth but their mechanism of action is unclear. We have investigated whether antiphospholipid antibodies occur more frequently in women having in-vitro fertilization (IVF) and whether their presence is associated with the likeli...

OBJECTIVE To test the validity of the fetal origins hypothesis and the classic twin method. DESIGN Follow up study of pairs of same sex twins in which both twins survived to age 6. SETTING Denmark. SUBJECTS 8495 twin individuals born 1870-1900, followed through to 31 December 1991. MAIN OUTCOME MEASURES Mortality calculated on a cohort basis. RESULTS Mortality among twins and the gene...

the interpretation of supernumerary chromosome is important for genetic counseling and prognosis. here, we used snp array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the neonatal intensive care unit of shahid sadoughi hospital in 2015.  clinical abnormalities identified in the newborn were dysmorphic...

maternal renal disease, essential hypertension, diabetes, and collagen vascular disease are all causes of fetal growth retardation,' and Dawes attributed 3500 of growth-retarded pregnancies to maternal vascular disease.13 There is increasing agreement that abnormal maternal vasculature is the most important common denominator in 'intrauterine growth retardation. There is less agreement, however...

BACKGROUND Q fever is a zoonosis caused by Coxiella burnetii. During pregnancy, it may result in obstetric complications, such as spontaneous abortion, intrauterine growth retardation, intrauterine fetal death, and premature delivery. Pregnant women are exposed to the risk of chronic Q fever. METHODS We included 53 pregnant women who received a diagnosis of Q fever. We compared the incidence ...

We report on two sisters with an unusual form of craniosynostosis, protruding nasal spine, micrognathia, short limbs, lung hypoplasia, absent or hypoplastic gallbladder, short intestine with ileal distention, hypoplastic uterus, and intrauterine growth retardation. This combination of defects appears to be a newly recognized and probably autosomal recessive disorder.

Twenty four children (five girls, 19 boys) who had intrauterine growth retardation were treated with daily subcutaneous biosynthetic human growth hormone, initially in a dose of either 15 or 30 U/m2/week for the first year and in the latter dose for the next two years. Six patients (one girl, five boys) had no dysmorphic signs and 18 (four girls, 14 boys) had signs of Russel-Silver syndrome. Al...